Article (Scientific journals)
A draft network of ligand–receptor-mediated multicellular signalling in human
Ramilowski, Jordan; Goldberg, Tatyana; Harshbarger, Jayson et al.
2015In Nature Communications, 6
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Abstract :
[en] Cell-to-cell communication across multiple cell types and tissues strictly governs proper functioning of metazoans and extensively relies on interactions between secreted ligands and cell-surface receptors. Herein, we present the first large-scale map of cell-to-cell communication between 144 human primary cell types. We reveal that most cells express tens to hundreds of ligands and receptors to create a highly connected signalling network through multiple ligand–receptor paths. We also observe extensive autocrine signalling with approximately two-thirds of partners possibly interacting on the same cell type. We find that plasma membrane and secreted proteins have the highest cell-type specificity, they are evolutionarily younger than intracellular proteins, and that most receptors had evolved before their ligands. We provide an online tool to interactively query and visualize our networks and demonstrate how this tool can reveal novel cell-to-cell interactions with the prediction that mast cells signal to monoblastic lineages via the CSF1–CSF1R interacting pair.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group)
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Ramilowski, Jordan;  RIKEN Center for Life Science Technologies > Division of Genomic Technologies
Goldberg, Tatyana;  Technische Universität München (TUM) > Department for Bioinformatics and Computational Biology-I12 ; Center of Doctoral Studies in Informatics and its Application (CeDoSIA) > TUM Graduate School
Harshbarger, Jayson;  RIKEN Center for Life Science Technologies > Division of Genomic Technologies
Kloppman, Edda;  Technische Universität München (TUM) > Department for Bioinformatics and Computational Biology-I12
Lizio, Marina;  RIKEN Center for Life Science Technologies > Division of Genomic Technologies
SATAGOPAM, Venkata ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Itoh, Masayoshi;  RIKEN Center for Life Science Technologies > Division of Genomic Technologies ; RIKEN Preventive Medicine and Diagnosis Innovation Program
Kawaji, Hideya;  RIKEN Preventive Medicine and Diagnosis Innovation Program ; RIKEN Center for Life Science Technologies > Division of Genomic Technologies
Carninci;  RIKEN Center for Life Science Technologies > Division of Genomic Technologies
Rost, Burkhard;  Technische Universität München (TUM) > Department for Bioinformatics and Computational Biology-I12 ; TUM Graduate School > Center of Doctoral Stuadies in Informatics and its Application (CeDoSIA)
Forrest, Alistair;  RIKEN Center for Life Science Technologies > Division of Genomic Technologies ; Harry Perkins Institute of Medical Research > QEII Medical Centre and Centre for Medical Research, the University of Western Australia
External co-authors :
yes
Language :
English
Title :
A draft network of ligand–receptor-mediated multicellular signalling in human
Publication date :
22 July 2015
Journal title :
Nature Communications
ISSN :
2041-1723
Publisher :
Nature Pub.lishing Group, London, United Kingdom
Volume :
6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 24 April 2016

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