Abnormalities, Drug-Induced/genetics; Animals; Bone Development/drug effects/genetics; Bone and Bones/abnormalities; Gene Expression Regulation, Developmental/physiology; Mice; Teratogens/toxicity
Abstract :
[en] Skeletal variations are common in humans, and potentially are caused by genetic as well as environmental factors. We here review molecular principles in skeletal development to develop a knowledge base of possible alterations that could explain variations in skeletal element number, shape or size. Environmental agents that induce variations, such as teratogens, likely interact with the molecular pathways that regulate skeletal development.
