Article (Scientific journals)
Dual bioactivity of resveratrol fatty alcohols: differentiation of neural stem cells and modulation of neuroinflammation
Hauss, Frederique; Liu, Jiawei; Michelucci, Alessandro et al.
2007In Bioorganic & Medicinal Chemistry Letters, 17 (15), p. 4218-4222
Peer reviewed
 

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Keywords :
Resveratrol fatty alcohols; Neuroinflammation; Neural stem cells; Microglia; Neurodegenerative diseases
Abstract :
[en] The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and omega-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies.
Disciplines :
Life sciences: Multidisciplinary, general & others
Identifiers :
UNILU:UL-ARTICLE-2012-463
Author, co-author :
Hauss, Frederique
Liu, Jiawei
Michelucci, Alessandro ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Coowar, Djalil
Morga, Eleonora ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Heuschling, Paul ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Luu, Bang
External co-authors :
yes
Language :
English
Title :
Dual bioactivity of resveratrol fatty alcohols: differentiation of neural stem cells and modulation of neuroinflammation
Publication date :
2007
Journal title :
Bioorganic & Medicinal Chemistry Letters
ISSN :
0960-894X
eISSN :
1464-3405
Publisher :
Elsevier Science, Oxford, United Kingdom
Volume :
17
Issue :
15
Pages :
4218-4222
Peer reviewed :
Peer reviewed
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since 11 April 2016

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