Reference : The HSSP database of protein structure sequence alignments
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
The HSSP database of protein structure sequence alignments
Schneider, Reinhard mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Sander, C. [> >]
Nucleic Acids Research
Oxford University Press
Yes (verified by ORBilu)
United Kingdom
[en] HSSP is a derived database merging structural three dimensional (3-D) and sequence one dimensional (1-D) information. For each protein of known 3-D structure from the Protein Data Bank (PDB), the database has a multiple sequence alignment of all available homologues and a sequence profile characteristic of the family. The list of homologues is the result of a database search in Swissprot using a position-weighted dynamic programming method for sequence profile alignment (MaxHom). The database is updated frequently. The listed homologues are very likely to have the same 3-D structure as the PDB protein to which they have been aligned. As a result, the database is not only a database of aligned sequence families, but also a database of implied secondary and tertiary structures covering 27% of all Swissprotstored sequences.

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