Article (Scientific journals)
Fuzzy oil drop model to interpret the structure of antifreeze proteins and their mutants
Banach, Mateusz; Prymula, Katarzyna; Jurkowski, Wiktor et al.
2012In Journal of Molecular Modeling, 18 (1), p. 229-237
 

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Keywords :
Antifreeze; Hydrophobicity.; Intermediates.; Mutants; Protein structure
Abstract :
[en] Mutations in proteins introduce structural changes and influence biological activity: the specific effects depend on the location of the mutation. The simple method proposed in the present paper is based on a two-step model of in silico protein folding. The structure of the first intermediate is assumed to be determined solely by backbone conformation. The structure of the second one is assumed to be determined by the presence of a hydrophobic center. The comparable structural analysis of the set of mutants is performed to identify the mutant-induced structural changes. The changes of the hydrophobic core organization measured by the divergence entropy allows quantitative comparison estimating the relative structural changes upon mutation. The set of antifreeze proteins, which appeared to represent the hydrophobic core structure accordant with "fuzzy oil drop" model was selected for analysis.
Disciplines :
Biochemistry, biophysics & molecular biology
Identifiers :
UNILU:UL-ARTICLE-2012-581
Author, co-author :
Banach, Mateusz
Prymula, Katarzyna
Jurkowski, Wiktor ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Konieczny, Leszek
Roterman, Irena
External co-authors :
yes
Language :
English
Title :
Fuzzy oil drop model to interpret the structure of antifreeze proteins and their mutants
Publication date :
2012
Journal title :
Journal of Molecular Modeling
ISSN :
0948-5023
Publisher :
Springer, Germany
Volume :
18
Issue :
1
Pages :
229-237
Available on ORBilu :
since 08 April 2016

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