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Improving BDD-based attractor detection for synchronous Boolean networks
Qu, Hongyang; Yuan, Qixia; Pang, Jun et al.
2015In Proceedings of the 7th Asia-Pacific Symposium on Internetware
Peer reviewed
 

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Keywords :
Boolean networks; systems biology; binary decision diagram
Abstract :
[en] Boolean networks are an important formalism for modelling biological systems and have attracted much attention in recent years. An important direction in Boolean networks is to exhaustively find attractors, which represent steady states when a biological network evolves for a long term. In this paper, we propose a new approach to improve the efficiency of BDD-based attractor detection. Our approach includes a monolithic algorithm for small networks, an enumerative strategy to deal with large networks, and two heuristics on ordering BDD variables. We demonstrate the performance of our approach on a number of examples, and compare it with one existing technique in the literature.
Disciplines :
Computer science
Author, co-author :
Qu, Hongyang;  University of Sheffield
Yuan, Qixia ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Computer Science and Communications Research Unit (CSC)
Pang, Jun  ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Computer Science and Communications Research Unit (CSC) ; University of Luxembourg > Interdisciplinary Centre for Security, Reliability and Trust (SNT)
Mizera, Andrzej ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Computer Science and Communications Research Unit (CSC)
External co-authors :
yes
Language :
English
Title :
Improving BDD-based attractor detection for synchronous Boolean networks
Publication date :
2015
Event name :
7th Asia-Pacific Symposium on Internetware
Event date :
06-11-2015
Audience :
International
Main work title :
Proceedings of the 7th Asia-Pacific Symposium on Internetware
Publisher :
ACM
Peer reviewed :
Peer reviewed
FnR Project :
FNR7814267 - New Approaches To Parameter Estimation Of Gene Regulatory Networks, 2014 (01/03/2014-14/01/2018) - Qixia Yuan
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