Reference : Genetics of Parkinson's disease.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/24436
Genetics of Parkinson's disease.
English
Kumar, Kishore R. [> >]
Djarmati-Westenberger, Ana [> >]
Grünewald, Anne [> >]
2011
Seminars in neurology
31
5
433-40
Yes (verified by ORBilu)
0271-8235
1098-9021
United States
[en] Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Mutation ; Parkinson Disease/genetics/physiopathology
[en] The identification of genes contributing to Parkinson's disease (PD) has allowed for an improved understanding of the underlying pathogenesis of the disorder. The authors review the rapidly growing field of PD genetics, with a focus on the clinical, genetic, and pathophysiologic features of well-validated monogenic forms of PD caused by mutations in the SNCA, LRRK2, PARKIN, PINK1, DJ-1, and ATP13A2 genes. In addition, they discuss mutations in the GBA gene, which increase susceptibility for PD. The authors also evaluate the implications of genome-wide association studies and stem cell-derived disease models and give recommendations for genetic testing.
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/10993/24436
10.1055/s-0031-1299782
(c) Thieme Medical Publishers.

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