Reference : Susceptibility-Weighted MRI for Deep Brain Stimulation: Potentials in Trajectory Planning

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Anatomy (cytology, histology, embryology...) & physiology Engineering, computing & technology : Multidisciplinary, general & others Human health sciences : Surgery
	To cite this reference:	http://hdl.handle.net/10993/23613

Title :	Susceptibility-Weighted MRI for Deep Brain Stimulation: Potentials in Trajectory Planning
Language :	English
Author, co-author :	Hertel, Frank [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Husch, Andreas [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Dooms, Georges [Centre Hospitalier de Luxembourg > Neuroradiology]
	Bernard, Florian [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Gemmar, Peter [Trier University of Applied Sciences > Computerscience]
Publication date :	2015
Journal title :	Stereotactic and Functional Neurosurgery
Publisher :	S. Karger
Volume :	93
Issue/season :	5
Pages :	303-308
Peer reviewed :	Yes (verified by ORBilu)
Audience :	International
ISSN :	1011-6125
e-ISSN :	1423-0372
Keywords :	[en] deep brain stimulation ; susceptibility-weighted MRI
Abstract :	[en] Background: Deep brain stimulation (DBS) trajectory plan- ning is mostly based on standard 3-D T1-weighted gado- linium-enhanced MRI sequences (T1-Gd). Susceptibility- weighted MRI sequences (SWI) show neurovascular struc- tures without the use of contrast agents. The aim of this study was to investigate whether SWI might be useful in DBS trajectory planning. Methods: We performed bilateral DBS planning using conventional T1-Gd images of 10 patients with different kinds of movement disorders. Afterwards, we matched SWI sequences and compared the visibility of vas- cular structures in both imaging modalities. Results: By ana- lyzing 100 possible trajectories, we found a potential vascu- lar conflict in 13 trajectories based on T1-Gd in contrast to 53 in SWI. Remarkably, all vessels visible in T1-Gd were also de- picted in SWI, whereas SWI showed many additional vascular structures which could not be identified in T1-Gd. Conclu- sion/Discussion: The sensitivity for detecting neurovascular structures for DBS planning seems to be significantly higher in SWI. As SWI does not require a contrast agent, we suggest that SWI may be a valuable alternative to T1-Gd MRI for DBS trajectory planning. Furthermore, the data analysis suggests that vascular interactions of DBS trajectories might be more frequent than expected from the very low incidence of symptomatic bleedings. The explanation for this is currently the subject of debate and merits further studies.
Research centres :	Luxembourg Centre for Systems Biomedicine (LCSB): Systems Control (Goncalves Group) ; Centre Hospitalier de Luxembourg: National Department of Neurosurgery (Hertel Group)
Funders :	Fonds National de la Recherche - FnR
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/10993/23613
DOI :	10.1159/000433445

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