[en] Aging-related biomolecular changes in the human brain are thought to be associated with an increased risk for neurodegenerative diseases. In particular, aging and Parkinson’s disease (PD) share various molecular hallmarks, including a gradual decline in dopamine synthesis and increased levels of deleted mitochondrial DNA. While some specific mechanistic links between brain aging and PD have been proposed and investigated previously, systematic analyses of shared molecular alterations at a genome-scale level are required to obtain a better understanding of the affected cellular processes and their interrelations.
We present a joint analysis of high-throughput brain transcriptomics data from PD patients and unaffected individuals from different adult age groups using a statistical meta-analysis and a recently published pathway and network analysis approach.
Our analyses provide statistical evidence for specific functional associations between molecular network changes in PD and aging, identify new significant joint pathway deregulations and suggest mechanistic explanations for the observed age-dependence of PD risk.
Research center :
Luxembourg Centre for Systems Biomedicine (LCSB)
Disciplines :
Biotechnology Neurology
Author, co-author :
GLAAB, Enrico ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
SCHNEIDER, Reinhard ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
External co-authors :
no
Language :
English
Title :
Shared alterations in the human brain transcriptome during adult aging and in Parkinson's disease
Publication date :
15 June 2015
Event name :
EMBO Symposium on Mechanisms of Neurodegeneration 2015
Event organizer :
European Molecular Biology Organization, European Molecular Biology Laboratory
Event place :
Heidelberg, Germany
Event date :
from 14-06-2015 to 17-06-2015
Audience :
International
FnR Project :
FNR5782168 - Exploring Parkinson'S Disease Inhibitor Efficacy On A Non-dopaminergic Target, 2013 (01/12/2013-31/05/2016) - Enrico Glaab