[en] In the model plant Arabidopsis thaliana, the concentration of cytosolic-free Ca2+ ([Ca2+]cyt) oscillates with a circadian rhythm. We are investigating the regulation and role of these oscillations both experimentally and mathematically. Through systems identification, we have developed simple mathematical models from a single experiment measuring [Ca2+]cyt and the promoter activity of CIRCADIAN CLOCK ASSOCIATED 1 (CCA1). Through validation with 4 contrasting datasets, including a clock-arrhythmic transgenic line (CCA1 overexpressor), we demonstrate the necessity for a light input pathway to regulate basal [Ca2+]cyt levels.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Neil, D.
Goncalves, Jorge ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Webb, A.R.
External co-authors :
yes
Language :
English
Title :
Mathematical models of circadian Ca2+ oscillations
Publication date :
2007
Event name :
The eighth International Conference on Systems Biology
Event place :
Long Beach, United States
Event date :
October 1 -6, 2007
Main work title :
Proceedings of the eighth International Conference on Systems Biology