Mathematical models of circadian Ca2+ oscillations

Reference : Mathematical models of circadian Ca2+ oscillations


	Document type :	Scientific congresses, symposiums and conference proceedings : Paper published in a book
	Discipline(s) :	Engineering, computing & technology : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/10993/20787

Title :	Mathematical models of circadian Ca2+ oscillations
Language :	English
Author, co-author :	Neil, D. [> >]
	Goncalves, Jorge [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Webb, A.R. []
Publication date :	2007
Main document title :	Proceedings of the eighth International Conference on Systems Biology
Peer reviewed :	Yes
Event name :	The eighth International Conference on Systems Biology
Event date :	October 1 -6, 2007
Event place (city) :	Long Beach
Event country :	USA
Abstract :	[en] In the model plant Arabidopsis thaliana, the concentration of cytosolic-free Ca2+ ([Ca2+]cyt) oscillates with a circadian rhythm. We are investigating the regulation and role of these oscillations both experimentally and mathematically. Through systems identification, we have developed simple mathematical models from a single experiment measuring [Ca2+]cyt and the promoter activity of CIRCADIAN CLOCK ASSOCIATED 1 (CCA1). Through validation with 4 contrasting datasets, including a clock-arrhythmic transgenic line (CCA1 overexpressor), we demonstrate the necessity for a light input pathway to regulate basal [Ca2+]cyt levels.
Permalink :	http://hdl.handle.net/10993/20787
Other URL :	http://www.icsb-2007.org/proceedings/abstracts/F08.pdf

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