Reference : Comparison of ODE-based models for reactive oxygen species regulation system
Scientific congresses, symposiums and conference proceedings : Paper published in a journal
Physical, chemical, mathematical & earth Sciences : Multidisciplinary, general & others
Computational Sciences
http://hdl.handle.net/10993/20466
Comparison of ODE-based models for reactive oxygen species regulation system
English
Ignatenko, Andrew mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Engineering Research Unit >]
Kolodkin, Alexey mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Peters, Bernhard mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Engineering Research Unit >]
Balling, Rudi mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Jun-2014
Proceedings of ICCSA 2014
199-203
Yes
International
4th International Conference on Complex Systems and Applications
from 23-06-2014 to 26-06-2014
Normandie University
Le Havre
France
[en] Nonlinear system ; ODE model ; reactive oxygen species
[en] Reactive oxygen species (ROS) play important role in the functioning of any cell and especially in the lifecycle of mitochondria. Since the action of ROS can be both positive and negative then the remarkable role can be played by ROS regulation system. We constructed three different ODE based kinetic models of different complexity for the ROS management system and shown the difference in the dynamics of these systems under different conditions. Using results of numerical simulation we showed that extraction of some subsystems can make the model more unstable. We also introduced the objective function for comparison of the models with structure of different complexity
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
http://hdl.handle.net/10993/20466

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