Biexcitability and Bursting Mechanisms in Neural and Genetic Circuits

Reference : Biexcitability and Bursting Mechanisms in Neural and Genetic Circuits


	Document type :	Scientific congresses, symposiums and conference proceedings : Paper published in a book
	Discipline(s) :	Life sciences : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/10993/20330

Title :	Biexcitability and Bursting Mechanisms in Neural and Genetic Circuits
Language :	English
Author, co-author :	Gifany, Peyman []
	Goncalves, Jorge [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Publication date :	2014
Main document title :	The proceedings of the 19th World Congress The International Federation of Automatic Control
Peer reviewed :	Yes
Event name :	19th World Congress The International Federation of Automatic Control
Event date :	August 24-29, 2014
Event place (city) :	Cape Town
Event country :	South Africa
Abstract :	[en] This paper compares mechanisms for generating repetitive spikes (bursts) in neural and transcriptional circuits. Neurons generate bursts followed by refractory periods controlled by ion channels in the membrane. In contrast, in gene transcription the bursts occur during a short time period followed by silent periods regulated by sis-regulatory elements. The role of excitability in producing different patterns of bursts is discussed by comparing the topology of a neural model with natural and synthetic transcriptional genetic circuits. In particular, a special bi-excitable architecture which embeds two excitable states are compared in these systems.
Permalink :	http://hdl.handle.net/10993/20330

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Limited access	Bursting Mechanisms in Neural Activity and Gene Transcription.pdf		Author preprint	610.16 kB	Request a copy

All documents in ORBi^lu are protected by a user license.