The Arabidopsis circadian clock incorporates a cADPR-based feedback loop

Reference : The Arabidopsis circadian clock incorporates a cADPR-based feedback loop


	Document type :	Scientific journals : Article
	Discipline(s) :	Engineering, computing & technology : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/10993/20317

Title :	The Arabidopsis circadian clock incorporates a cADPR-based feedback loop
Language :	English
Author, co-author :	Dodd, A. N. [> >]
	Gardner, M. J. [> >]
	Hotta, C. T. [> >]
	Hubbard, K. E. [> >]
	Dalchau, N. [> >]
	Love, J. [> >]
	Assie, J. M. [> >]
	Robertson, F. C. [> >]
	Jakobsen, M. K. [> >]
	Goncalves, Jorge [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Sanders, D. [> >]
	Webb, A. A. R. [> >]
Publication date :	Dec-2007
Journal title :	SCIENCE
Volume :	318
Issue/season :	5857
Pages :	1789-1792
Peer reviewed :	Yes (verified by ORBi^lu)
ISSN :	0036-8075
Abstract :	[en] Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator’s transcriptional feedback loops and drives circadian oscillations of Ca2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock.
Permalink :	http://hdl.handle.net/10993/20317
DOI :	10.1126/science.1146757

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