Article (Scientific journals)
Applying systems biology methods to the study of human physiology in extreme environments
Edwards, Lindsay; Thiele, Ines
2013In Extreme Physiology and Medicine, 2 (8)
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Abstract :
[en] Systems biology is defined in this review as ‘an iterative process of computational model building and experimental model revision with the aim of understanding or simulating complex biological systems’. We propose that, in practice, systems biology rests on three pillars: computation, the omics disciplines and repeated experimental perturbation of the system of interest. The number of ethical and physiologically relevant perturbations that can be used in experiments on healthy humans is extremely limited and principally comprises exercise, nutrition, infusions (e.g. Intralipid), some drugs and altered environment. Thus, we argue that systems biology and environmental physiology are natural symbionts for those interested in a system-level understanding of human biology. However, despite excellent progress in high-altitude genetics and several proteomics studies, systems biology research into human adaptation to extreme environments is in its infancy. A brief description and overview of systems biology in its current guise is given, followed by a mini review of computational methods used for modelling biological systems. Special attention is given to high-altitude research, metabolic network reconstruction and constraint-based modelling.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Edwards, Lindsay;  King’s College London > Centre of Human & Aerospace Physiological Sciences, School of Biomedical Sciences
Thiele, Ines ;  University of Iceland > Center for Systems Biology
External co-authors :
yes
Language :
English
Title :
Applying systems biology methods to the study of human physiology in extreme environments
Publication date :
2013
Journal title :
Extreme Physiology and Medicine
ISSN :
2046-7648
Publisher :
BioMed Central Ltd, London, United Kingdom
Volume :
2
Issue :
8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 19 July 2014

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