Reference : Alpha-synuclein repeat variants and survival in Parkinson's disease.

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Genetics & genetic processes
	To cite this reference:	http://hdl.handle.net/10993/17197

Title :	Alpha-synuclein repeat variants and survival in Parkinson's disease.
Language :	English
Author, co-author :	Chung, Sun Ju [> >]
	Biernacka, Joanna M. [> >]
	Armasu, Sebastian M. [> >]
	Anderson, Kari [> >]
	Frigerio, Roberta [> >]
	Aasly, Jan O. [> >]
	Annesi, Grazia [> >]
	Bentivoglio, Anna Rita [> >]
	Brighina, Laura [> >]
	Chartier-Harlin, Marie-Christine [> >]
	Goldwurm, Stefano [> >]
	Hadjigeorgiou, Georgios [> >]
	Jasinska-Myga, Barbara [> >]
	Jeon, Beom Seok [> >]
	Kim, Yun Joong [> >]
	Krüger, Rejko [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
	Lesage, Suzanne [> >]
	Markopoulou, Katerina [> >]
	Mellick, George [> >]
	Morrison, Karen E. [> >]
	Puschmann, Andreas [> >]
	Tan, Eng-King [> >]
	Crosiers, David [> >]
	Theuns, Jessie [> >]
	Van Broeckhoven, Christine [> >]
	Wirdefeldt, Karin [> >]
	Wszolek, Zbigniew K. [> >]
	Elbaz, Alexis [> >]
	Maraganore, Demetrius M. [> >]
Publication date :	2014
Journal title :	Movement Disorders
Peer reviewed :	Yes (verified by ORBilu)
ISSN :	0885-3185
e-ISSN :	1531-8257
Keywords :	[en] Parkinson's disease ; association ; gene ; survival ; α-synuclein
Abstract :	[en] OBJECTIVES: To determine whether alpha-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). METHODS: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. RESULTS: Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01). CONCLUSIONS: In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in PD. Further studies of alpha-synuclein's role in disease progression and long-term outcomes are needed. (c) 2014 International Parkinson and Movement Disorder Society.
Research centres :	Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
Permalink :	http://hdl.handle.net/10993/17197
DOI :	10.1002/mds.25841
Commentary :	(c) 2014 Movement Disorder Society.

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