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Article (Scientific journals)
Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study.
Elbaz, Alexis; Nelson, Lorene M.; Payami, Haydeh et al.
2006In Lancet Neurology, 5 (11), p. 917-23
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Keywords :
Aged; Confidence Intervals; Female; Genetic Predisposition to Disease; Humans; International Cooperation; Linkage Disequilibrium; Male; Meta-Analysis as Topic; Middle Aged; Odds Ratio; Parkinson Disease/epidemiology/genetics; Polymorphism, Single Nucleotide/genetics
Abstract :
[en] BACKGROUND: A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain. METHODS: Investigators from three Michael J Fox Foundation for Parkinson's Research-funded genetics consortia-comprising 14 teams-contributed DNA samples from 5526 patients with Parkinson's disease and 6682 controls, which were genotyped for the 13 SNPs. Most (88%) participants were of white, non-Hispanic descent. We assessed log-additive genetic effects using fixed and random effects models stratified by team and ethnic origin, and tested for heterogeneity across strata. A meta-analysis was undertaken that incorporated data from the original genome-wide study as well as subsequent replication studies. FINDINGS: In fixed and random-effects models no associations with any of the 13 SNPs were identified (odds ratios 0.89 to 1.09). Heterogeneity between studies and between ethnic groups was low for all SNPs. Subgroup analyses by age at study entry, ethnic origin, sex, and family history did not show any consistent associations. In our meta-analysis, no SNP showed significant association (summary odds ratios 0.95 to 1.08); there was little heterogeneity except for SNP rs7520966. INTERPRETATION: Our results do not lend support to the finding that the 13 SNPs reported in the original genome-wide association study are genetic susceptibility factors for Parkinson's disease.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
Disciplines :
Genetics & genetic processes
Author, co-author :
Elbaz, Alexis
Nelson, Lorene M.
Payami, Haydeh
Ioannidis, John P. A.
Fiske, Brian K.
Annesi, Grazia
Carmine Belin, Andrea
Factor, Stewart A.
Ferrarese, Carlo
Hadjigeorgiou, Georgios M.
Higgins, Donald S.
Kawakami, Hideshi
KRÜGER, Rejko ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Marder, Karen S.
Mayeux, Richard P.
Mellick, George D.
Nutt, John G.
Ritz, Beate
Samii, Ali
Tanner, Caroline M.
Van Broeckhoven, Christine
Van Den Eeden, Stephen K.
Wirdefeldt, Karin
Zabetian, Cyrus P.
Dehem, Marie
Montimurro, Jennifer S.
Southwick, Audrey
Myers, Richard M.
Trikalinos, Thomas A.
More authors (19 more) Less
Language :
English
Title :
Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study.
Publication date :
2006
Journal title :
Lancet Neurology
ISSN :
1474-4422
Volume :
5
Issue :
11
Pages :
917-23
Peer reviewed :
Peer reviewed
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