Reference : Genetic causes of Parkinson's disease: extending the pathway.
Scientific journals : Article
Life sciences : Genetics & genetic processes
Genetic causes of Parkinson's disease: extending the pathway.
Riess, O. [> >]
Krüger, Rejko mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
Hochstrasser, H. [> >]
Soehn, A. S. [> >]
Nuber, S. [> >]
Franck, T. [> >]
Berg, D. [> >]
Journal of neural transmission. Supplementum
Yes (verified by ORBilu)
[en] Animals ; Chromosome Mapping ; Humans ; Iron/metabolism ; Mitochondrial Diseases/metabolism ; Parkinson Disease/genetics ; Phosphorylation ; alpha-Synuclein/metabolism
[en] The functional characterization of identified disease genes in monogenic forms of Parkinson's disease (PD) allows first insights into molecular pathways leading to neurodegeneration and dysfunction of the nigrostriatal system. There is increasing evidence that disturbance of the ubiquitin proteasome pathway is one important feature of this process underscoring the relevance of protein misfolding and accumulation in the neurodegenerative process of PD. Other genes are involved in mitochondrial homeostasis and still others link newly identified signalling pathways to the established paradigm of oxidative stress in PD. Additional factors are posttranslational modifications of key proteins such as phosphorylation. Also, molecular data support the role of altered iron metabolism in PD. Here we describe known genes and novel genetic susceptibility factors and define their role in neurodegeneration.
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)

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