No full text
Article (Scientific journals)
Therapeutic strategies for Parkinson's disease based on data derived from genetic research.
Riess, Olaf; Berg, Daniela; KRÜGER, Rejko et al.
2003In Journal of Neurology, 250 Suppl 1, p. 3-10
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Adjuvants, Immunologic; Animals; Antioxidants/therapeutic use; Apoptosis/genetics/physiology; Disease Models, Animal; Genetics, Medical/methods; Humans; Immunotherapy, Active; Iron/physiology; Microglia/metabolism; Mitochondria/metabolism; Nerve Tissue Proteins/metabolism; Parkinson Disease/genetics/metabolism/pathology/therapy; Substantia Nigra/metabolism; Synucleins; alpha-Synuclein
Abstract :
[en] Following the identification of mutations in alpha-synuclein as the cause of some rare forms of familial Parkinson's disease (PD), genetic research has uncovered numerous gene loci of PD. Meanwhile, several neurodegenerative diseases have been shown to accumulate a-synuclein in neuronal and glial cells summarizing this group of diseases as synucleinopathies. All currently known gene defects causing PD alter the ubiquitin-proteasomal pathway of protein degradation. Identification of these disease mutations allows studying the functional consequences which lead to cellular dysfunction and cell death in cell culture and transgenic animal models, to identify therapeutic targets and to test potential protective strategies in these models.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
Disciplines :
Genetics & genetic processes
Author, co-author :
Riess, Olaf
Berg, Daniela
KRÜGER, Rejko ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Schulz, Jorg B.
Language :
English
Title :
Therapeutic strategies for Parkinson's disease based on data derived from genetic research.
Publication date :
2003
Journal title :
Journal of Neurology
ISSN :
0340-5354
eISSN :
1432-1459
Publisher :
Dr. Dietrich Steinkopff Verlag, Germany
Volume :
250 Suppl 1
Pages :
I3-10
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 27 June 2014

Statistics


Number of views
57 (0 by Unilu)
Number of downloads
0 (0 by Unilu)

Scopus citations®
 
6
Scopus citations®
without self-citations
6
OpenCitations
 
4
WoS citations
 
3

Bibliography


Similar publications



Contact ORBilu