Genetic analysis of the alpha2-macroglobulin gene in early- and late-onset Parkinson's disease.

Krüger, Rejko; Menezes-Saecker, A. M.; Schols, L.; Kuhn, W.; Muller, T.; Woitalla, D.; Berg, D.; Berger, K.; Przuntek, H.; Epplen, J. T.; Riess, O.

Reference : Genetic analysis of the alpha2-macroglobulin gene in early- and late-onset Parkinson'...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Genetics & genetic processes
	To cite this reference:	http://hdl.handle.net/10993/17118

Title :	Genetic analysis of the alpha2-macroglobulin gene in early- and late-onset Parkinson's disease.
Language :	English
Author, co-author :	Krüger, Rejko [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
	Menezes-Saecker, A. M. [> >]
	Schols, L. [> >]
	Kuhn, W. [> >]
	Muller, T. [> >]
	Woitalla, D. [> >]
	Berg, D. [> >]
	Berger, K. [> >]
	Przuntek, H. [> >]
	Epplen, J. T. [> >]
	Riess, O. [> >]
Publication date :	2000
Journal title :	Neuroreport
Volume :	11
Issue/season :	11
Pages :	2439-42
Peer reviewed :	Yes (verified by ORBi^lu)
ISSN :	0959-4965
Country :	ENGLAND
Keywords :	[en] Age of Onset ; Aged ; Alleles ; Apolipoprotein E4 ; Apolipoproteins E/genetics ; Female ; Gene Deletion ; Genotype ; Humans ; Male ; Parkinson Disease/genetics ; Polymorphism, Genetic/genetics ; alpha-Macroglobulins/genetics
Abstract :	[en] Recent association studies investigating polymorphisms in the alpha2-macroglobulin (A2M) gene provided evidence for an involvement of this protease inhibitor in the pathogenesis of Alzheimer's disease (AD). The partially overlapping pathology between AD and Parkinson's disease (PD) led us to investigate the role of A2M in PD. We performed association studies in a large sample of 328 German PD patients and 322 closely matched healthy controls. Analyzing the Val1000Ile polymorphism and a pentanucleotide deletion in the 5' splice site of exon 18 of the A2M gene we found an excess of homozygosity for the A2M deletion in early-onset PD (EOPD) patients (age at onset < 50 years) compared to late-onset PD (LOPD) patients (age at onset > 50 years; p = 0.008, p(p)c = 0.064, chi2 = 7.017). Therefore our data might indicate an age at onset modulating effect of the homozygous A2M deletion in PD.
Research centres :	Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
Permalink :	http://hdl.handle.net/10993/17118

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