Reference : Genetic dissection of familial Parkinson's disease.
Scientific journals : Article
Life sciences : Genetics & genetic processes
Genetic dissection of familial Parkinson's disease.
Riess, O. [> >]
Jakes, R. [> >]
Krüger, Rejko mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
Molecular Medicine Today
Yes (verified by ORBilu)
[en] Amino Acid Sequence ; Animals ; Forecasting ; Genes, Dominant ; Genes, Recessive ; Humans ; Molecular Sequence Data ; Nerve Degeneration ; Nerve Tissue Proteins/physiology ; Parkinson Disease/genetics ; Synucleins ; alpha-Synuclein
[en] In the past few years, the genetic contribution to Parkinson's disease (PD) has gained major attention and has resulted in the identification of the first mutant gene, called alpha-synuclein, involved in the pathogenesis of autosomal-dominant PD. alpha-Synuclein is a major component of Lewy bodies, which are a neuropathological feature of PD. Furthermore, deletions in the parkin gene have been identified as the primary cause in rare forms of autosomal-recessive juvenile PD. The elucidation of polygenic changes in the dopamine pathway, mitochondrial dysfunction, and metabolism of xenobiotics is now technically possible by means of association and genotype studies. The increasing knowledge of the pathogenesis of PD at a molecular level will have important implications for the development of individual therapeutic strategies to prevent disease progression.
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)

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