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Genetic dissection of familial Parkinson's disease.
Riess, O.; Jakes, R.; Krüger, Rejko
1998In Molecular Medicine Today, 4 (10), p. 438-44
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Keywords :
Amino Acid Sequence; Animals; Forecasting; Genes, Dominant; Genes, Recessive; Humans; Molecular Sequence Data; Nerve Degeneration; Nerve Tissue Proteins/physiology; Parkinson Disease/genetics; Synucleins; alpha-Synuclein
Abstract :
[en] In the past few years, the genetic contribution to Parkinson's disease (PD) has gained major attention and has resulted in the identification of the first mutant gene, called alpha-synuclein, involved in the pathogenesis of autosomal-dominant PD. alpha-Synuclein is a major component of Lewy bodies, which are a neuropathological feature of PD. Furthermore, deletions in the parkin gene have been identified as the primary cause in rare forms of autosomal-recessive juvenile PD. The elucidation of polygenic changes in the dopamine pathway, mitochondrial dysfunction, and metabolism of xenobiotics is now technically possible by means of association and genotype studies. The increasing knowledge of the pathogenesis of PD at a molecular level will have important implications for the development of individual therapeutic strategies to prevent disease progression.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
Disciplines :
Genetics & genetic processes
Author, co-author :
Riess, O.
Jakes, R.
Krüger, Rejko ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Language :
English
Title :
Genetic dissection of familial Parkinson's disease.
Publication date :
1998
Journal title :
Molecular Medicine Today
ISSN :
1357-4310
Publisher :
Elsevier, Netherlands
Volume :
4
Issue :
10
Pages :
438-44
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 27 June 2014

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