Reference : Involvement of alpha-synuclein in Parkinson's disease and other neurodegenerative dis...
Scientific journals : Article
Scientific journals : Article
Involvement of alpha-synuclein in Parkinson's disease and other neurodegenerative disorders.
Krüger, Rejko mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
Muller, T. [> >]
Riess, O. [> >]
Journal of Neural Transmission
Yes (verified by ORBilu)
[en] Alzheimer Disease/genetics/metabolism/pathology ; Humans ; Nerve Degeneration/genetics/metabolism/pathology ; Nerve Tissue Proteins/genetics/metabolism ; Parkinson Disease/genetics/metabolism/pathology ; Synucleins ; alpha-Synuclein
[en] A major step in the elucidation of the pathogenesis of neurodegenerative disorders was the identification of a mutation in the alpha-synuclein gene in autosomal dominant Parkinson's disease (PD). Alpha-synuclein is the main component of Lewy bodies (LB), the neuropathological hallmark of PD. Moreover, a fragment of alpha-synuclein (NAC) is the second major component of amyloid plaques in Alzheimer's disease (AD). Recent studies of other neurodegenerative disorders such as dementia with LB (DLB), multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS) also revealed intracellular accumulations of alpha-synuclein in affected brain regions. This may indicate that these disorders partially share common pathogenic mechanisms. Recent data provide first insights into the physiological function of alpha-synuclein and support the concept of an essential role of alpha-synuclein in neurodegeneration. Increasing knowledge on the pathogenic molecular mechanisms of neurodegeneration and of the pathophysiological function of alpha-synuclein in particular may influence future development of therapeutic strategies in neurodegenerative disorders.
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)

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