Reference : Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasm...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening.
Nicola, George [> >]
Smith, Colin A. [> >]
Lucumi Moreno, Edinson mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Kuo, Mack R. [> >]
Karagyozov, Luchezar [> >]
Fidock, David A. [> >]
Sacchettini, James C. [> >]
Abagyan, Ruben [> >]
Biochemical and biophysical research communications
United States
[en] Animals ; Antimalarials/chemistry/pharmacology ; Binding Sites ; Caco-2 Cells ; Crystallography, X-Ray ; Drug Design ; Drug Evaluation, Preclinical ; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)/antagonists & inhibitors ; Humans ; Hydrogen Bonding ; Kinetics ; Malaria/drug therapy ; Models, Molecular ; Plasmodium falciparum/enzymology ; Triclosan/chemistry/pharmacology
[en] There is a dire need for novel therapeutics to treat the virulent malarial parasite, Plasmodium falciparum. Recently, the X-ray crystal structure of enoyl-acyl carrier protein reductase (ENR) in complex with triclosan has been determined and provides an opportunity for the rational design of novel inhibitors targeting the active site of ENR. Here, we report the discovery of several compounds by virtual screening and their experimental validation as high potency PfENR inhibitors.
Researchers ; Professionals ; Students

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