Reference : Building a kinetic model of trehalose biosynthesis in Saccharomyces cerevisiae.
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
Building a kinetic model of trehalose biosynthesis in Saccharomyces cerevisiae.
Smallbone, Kieran [> >]
Malys, Naglis [> >]
Messiha, Hanan L. [> >]
Wishart, Jill A. [> >]
Simeonidis, Evangelos mailto [University of Manchester > Manchester Centre for Integrative Systems Biology]
Methods in Enzymology
Methods in Systems Biology
Yes (verified by ORBilu)
United States
[en] Algorithms ; Computer Simulation ; Enzyme Assays ; Gene Expression Regulation, Fungal ; Glucose-6-Phosphate Isomerase/chemistry/physiology ; Glucosyltransferases/chemistry/physiology ; Glycolysis ; Kinetics ; Metabolic Networks and Pathways ; Models, Biological ; Phosphoglucomutase/chemistry/physiology ; Saccharomyces cerevisiae/enzymology/metabolism/physiology ; Saccharomyces cerevisiae Proteins/chemistry/physiology ; Stress, Physiological ; Systems Biology ; Trehalose/biosynthesis ; UTP-Glucose-1-Phosphate Uridylyltransferase/chemistry/physiology
[en] In this chapter, we describe the steps needed to create a kinetic model of a metabolic pathway based on kinetic data from experimental measurements and literature review. Our methodology is presented by utilizing the example of trehalose metabolism in yeast. The biology of the trehalose cycle is briefly reviewed and discussed.
Copyright (c) 2011 Elsevier Inc. All rights reserved.

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