| Reference : Systematic approaches to mouse mutagenesis. |
| Scientific journals : Article | |||
| Life sciences : Genetics & genetic processes | |||
| http://hdl.handle.net/10993/1566 | |||
| Systematic approaches to mouse mutagenesis. | |
| English | |
| Brown, S. D. [> >] | |
Balling, Rudi  [> >] | |
| 2001 | |
| Current Opinion in Genetics and Development | |
| 11 | |
| 3 | |
| 268-73 | |
| Yes | |
| 0959-437X | |
| England | |
| [en] Animals ; Ethylnitrosourea ; Genetic Variation ; Humans ; Mice ; Mice, Mutant Strains/genetics ; Mutagenesis ; Phenotype | |
| [en] A major challenge in post-genomics is the systematic determination of mammalian gene function. A variety of mouse mutagenesis technologies, both gene- and phenotype-driven, are being used to underpin systematic and comprehensive approaches to mammalian gene function studies. Recently, a number of centres have completed large-scale ENU mutagenesis programmes that employ a phenotype-driven approach to the generation of mouse mutants. The use of ENU mutagenesis represents a powerful and efficient approach to mammalian gene-function studies, but many parallel developments are needed in downstream technologies to properly harness the new enlarged mouse-mutant resources that are being created. | |
| http://hdl.handle.net/10993/1566 |
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