Reference : Systematic approaches to mouse mutagenesis.
Scientific journals : Article
Life sciences : Genetics & genetic processes
Systematic approaches to mouse mutagenesis.
Brown, S. D. [> >]
Balling, Rudi mailto [> >]
Current Opinion in Genetics and Development
[en] Animals ; Ethylnitrosourea ; Genetic Variation ; Humans ; Mice ; Mice, Mutant Strains/genetics ; Mutagenesis ; Phenotype
[en] A major challenge in post-genomics is the systematic determination of mammalian gene function. A variety of mouse mutagenesis technologies, both gene- and phenotype-driven, are being used to underpin systematic and comprehensive approaches to mammalian gene function studies. Recently, a number of centres have completed large-scale ENU mutagenesis programmes that employ a phenotype-driven approach to the generation of mouse mutants. The use of ENU mutagenesis represents a powerful and efficient approach to mammalian gene-function studies, but many parallel developments are needed in downstream technologies to properly harness the new enlarged mouse-mutant resources that are being created.

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