No full text
Article (Scientific journals)
A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression.
Faiella, A.; Wernig, M.; Consalez, G. G. et al.
2000In Human Molecular Genetics, 9 (2), p. 227-36
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Abnormalities, Drug-Induced/genetics; Abnormalities, Multiple/chemically induced/genetics; Animals; Anticonvulsants/toxicity; Carcinoma, Embryonal/genetics; Disease Models, Animal; Female; Fetal Weight/drug effects; Fetus/abnormalities/drug effects; Gene Expression Regulation, Developmental/drug effects; Genes, Homeobox/drug effects; Genes, Lethal; Humans; Maternal-Fetal Exchange/drug effects/genetics; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Pregnancy; Valproic Acid/toxicity
Abstract :
[en] Valproate (VPA) is one of several effective anti-epileptic and mood-stabilizing drugs, many of which are also potent teratogens in humans and several other mammalian species. Variable teratogenicity among inbred strains of laboratory mice suggests that genetic factors influence susceptibility. While studying the genetic basis for VPA teratogenicity in mice, we discovered that parental factors influence fetal susceptibility to induced malformations. Detailed examination of these malformations revealed that many were homeotic transformations. To test whether VPA, like retinoic acid (RA), alters HOX expression, pluripotent human embryonal carcinoma cells were treated with VPA or RA and Hox expression assessed. Altered expression of specific Hox genes may thus account for the homeotic transformations and other malformations found in VPA-treated fetuses.
Disciplines :
Genetics & genetic processes
Author, co-author :
Faiella, A.
Wernig, M.
Consalez, G. G.
Hostick, U.
Hofmann, C.
Hustert, E.
Boncinelli, E.
Balling, Rudi 
Nadeau, J. H.
Language :
English
Title :
A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression.
Publication date :
2000
Journal title :
Human Molecular Genetics
ISSN :
1460-2083
Publisher :
Oxford University Press, United Kingdom
Volume :
9
Issue :
2
Pages :
227-36
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 15 May 2013

Statistics


Number of views
59 (1 by Unilu)
Number of downloads
0 (0 by Unilu)

Scopus citations®
 
100
Scopus citations®
without self-citations
99
OpenCitations
 
81
WoS citations
 
84

Bibliography


Similar publications



Contact ORBilu