Reference : A locus for radiation-induced gastroschisis on mouse Chromosome 7.
Scientific journals : Article
Life sciences : Genetics & genetic processes
A locus for radiation-induced gastroschisis on mouse Chromosome 7.
Hillebrandt, S. [> >]
Streffer, C. [> >]
Montagutelli, X. [> >]
Balling, Rudi mailto []
Mammalian Genome : Official Journal of the International Mammalian Genome Society
Yes (verified by ORBilu)
[en] Abdominal Muscles/abnormalities/embryology/radiation effects ; Abnormalities, Radiation-Induced/genetics ; Animals ; Chromosome Mapping ; Chromosomes/genetics ; Crosses, Genetic ; Female ; Fetus/drug effects/metabolism ; Gastroschisis/genetics ; Genetic Markers ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Pregnancy ; X-Rays
[en] Gastroschisis (abdominal wall defects) occurs with a high frequency in the mouse inbred strain HLG compared with C57BL/6J mice. The risk of gastroschisis increases significantly after exposure to irradiation with X-rays during preimplantation development and follows a recessive mode of inheritance for the HLG susceptibility alleles. We have used a backcross strategy and genome-wide microsatellite typing to chromosomally map this trait. A suggestive linkage for a locus responsible for radiation-induced gastroschisis (Rigs1) was found in a region of mouse Chromosome 7.

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