Reference : Structure, expression and chromosomal location of the Oct-4 gene.
Scientific journals : Article
Life sciences : Genetics & genetic processes
Structure, expression and chromosomal location of the Oct-4 gene.
Yeom, Y. I. [> >]
Ha, H. S. [> >]
Balling, Rudi mailto []
Scholer, H. R. [> >]
Artzt, K. [> >]
Mechanisms of Development
Yes (verified by ORBilu)
[en] Animals ; Base Sequence ; Blotting, Southern ; Chromosome Mapping ; Cloning, Molecular ; Cosmids ; DNA ; DNA-Binding Proteins/biosynthesis/genetics/ultrastructure ; Electrophoresis, Gel, Pulsed-Field ; Gene Expression ; Major Histocompatibility Complex ; Mice ; Mice, Inbred Strains ; Molecular Sequence Data ; Multigene Family ; Octamer Transcription Factor-3 ; Polymerase Chain Reaction ; Transcription Factors/genetics ; Zygote/metabolism
[en] The map position of Oct-4 on mouse chromosome 17 is between Q and T regions in the Major Histocompatibility Complex (MHC), and it is physically located within 35 kb of a class I gene. Several Oct-4-related genes are present in the murine genome; one of them maps to chromosome 9. The genomic structure and sequence of Oct-4 determined in t-haplotypes reveals five exons, and shows no significant changes in the t12 mutant haplotype making it unlikely that Oct-4 and the t12 early embryonic lethal are the same gene. By in situ hybridization, detectable onset of zygotic Oct-4 expression does not occur until compaction begins at 8-cells, suggesting that there might be other regulatory factors responsible for initiating Oct-4 expression.

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