| Reference : Structure, expression and chromosomal location of the Oct-4 gene. |
| Scientific journals : Article | |||
| Life sciences : Genetics & genetic processes | |||
| http://hdl.handle.net/10993/1267 | |||
| Structure, expression and chromosomal location of the Oct-4 gene. | |
| English | |
| Yeom, Y. I. [> >] | |
| Ha, H. S. [> >] | |
Balling, Rudi  [] | |
| Scholer, H. R. [> >] | |
| Artzt, K. [> >] | |
| 1991 | |
| Mechanisms of Development | |
| 35 | |
| 3 | |
| 171-9 | |
| Yes (verified by ORBilu) | |
| 0925-4773 | |
| 1872-6356 | |
| IRELAND | |
| [en] Animals ; Base Sequence ; Blotting, Southern ; Chromosome Mapping ; Cloning, Molecular ; Cosmids ; DNA ; DNA-Binding Proteins/biosynthesis/genetics/ultrastructure ; Electrophoresis, Gel, Pulsed-Field ; Gene Expression ; Major Histocompatibility Complex ; Mice ; Mice, Inbred Strains ; Molecular Sequence Data ; Multigene Family ; Octamer Transcription Factor-3 ; Polymerase Chain Reaction ; Transcription Factors/genetics ; Zygote/metabolism | |
| [en] The map position of Oct-4 on mouse chromosome 17 is between Q and T regions in the Major Histocompatibility Complex (MHC), and it is physically located within 35 kb of a class I gene. Several Oct-4-related genes are present in the murine genome; one of them maps to chromosome 9. The genomic structure and sequence of Oct-4 determined in t-haplotypes reveals five exons, and shows no significant changes in the t12 mutant haplotype making it unlikely that Oct-4 and the t12 early embryonic lethal are the same gene. By in situ hybridization, detectable onset of zygotic Oct-4 expression does not occur until compaction begins at 8-cells, suggesting that there might be other regulatory factors responsible for initiating Oct-4 expression. | |
| http://hdl.handle.net/10993/1267 |
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