Reference : Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice.
Scientific journals : Article
Life sciences : Genetics & genetic processes
Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice.
Kessel, M. [> >]
Balling, Rudi mailto []
Gruss, P. [> >]
Yes (verified by ORBilu)
[en] Animals ; Animals, Newborn ; Cervical Vertebrae/abnormalities/anatomy & histology/pathology ; Genes, Homeobox ; Genetic Vectors ; Mice ; Mice, Transgenic ; Phenotype
[en] To understand the function of murine homeobox genes, a genetic analysis is mandatory. We generated gain-of-function mutants by introducing genomic sequences of the Hox-1.1 gene under the control of a chicken beta-actin promoter into mice. Our previous data had shown that these transgenic mice are nonviable after birth and are born with craniofacial abnormalities. In a subsequent detailed analysis of severely affected animals, malformations of the basioccipital bone, the atlas, and the axis were observed. Manifestation of an additional vertebra, a proatlas, occurred at the craniocervical transition. The dominant interference of the Hox-1.1 transgene with developmental programs seems to occur around day 9 of gestation, the time of neural crest migration and somite differentiation. We discuss the resulting phenotype with respect to a developmental control function of Hox-1.1.

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