Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice.

Reference : Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice.


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Genetics & genetic processes
	To cite this reference:	http://hdl.handle.net/10993/1264

Title :	Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice.
Language :	English
Author, co-author :	Kessel, M. [> >]
	Balling, Rudi []
	Gruss, P. [> >]
Publication date :	1990
Journal title :	Cell
Volume :	61
Issue/season :	2
Pages :	301-8
Peer reviewed :	Yes (verified by ORBi^lu)
ISSN :	0092-8674
e-ISSN :	1097-4172
Country :	UNITED STATES
Keywords :	[en] Animals ; Animals, Newborn ; Cervical Vertebrae/abnormalities/anatomy & histology/pathology ; Genes, Homeobox ; Genetic Vectors ; Mice ; Mice, Transgenic ; Phenotype
Abstract :	[en] To understand the function of murine homeobox genes, a genetic analysis is mandatory. We generated gain-of-function mutants by introducing genomic sequences of the Hox-1.1 gene under the control of a chicken beta-actin promoter into mice. Our previous data had shown that these transgenic mice are nonviable after birth and are born with craniofacial abnormalities. In a subsequent detailed analysis of severely affected animals, malformations of the basioccipital bone, the atlas, and the axis were observed. Manifestation of an additional vertebra, a proatlas, occurred at the craniocervical transition. The dominant interference of the Hox-1.1 transgene with developmental programs seems to occur around day 9 of gestation, the time of neural crest migration and somite differentiation. We discuss the resulting phenotype with respect to a developmental control function of Hox-1.1.
Permalink :	http://hdl.handle.net/10993/1264

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