Reference : A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cell...
Scientific journals : Article
Life sciences : Genetics & genetic processes
A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine.
Duprey, P. [> >]
Chowdhury, K. [> >]
Dressler, G. R. [> >]
Balling, Rudi mailto [> >]
Simon, D. [> >]
Guenet, J. L. [> >]
Gruss, P. [> >]
Genes and Development
Yes (verified by ORBilu)
[en] Amino Acid Sequence ; Animals ; Base Sequence ; Blotting, Southern ; Chromosome Mapping ; DNA ; DNA Probes ; Drosophila/genetics ; Electrophoresis, Agar Gel ; Embryonic and Fetal Development ; Genes, Homeobox ; Intestines/cytology/embryology ; Mice ; Molecular Sequence Data ; Sequence Homology, Nucleic Acid ; Species Specificity ; Transcription, Genetic
[en] A mouse gene, Cdx-1, was isolated from an embryonic cDNA library using a Drosophila caudal gene probe. The deduced amino acid sequence of Cdx-1 contains conserved sequence domains along the entire gene, as well as a highly conserved caudal-type homeo box. A structural comparison suggests a common ancestral origin of mouse Cdx-1 and Drosophila caudal. The expression of Cdx-1 during embryogenesis was analyzed by Northern blotting and in situ hybridization. Cdx-1-specific transcripts are localized in the epithelial lining of the intestines beginning at 14 days' gestation. The expression of Cdx-1 in the intestine continues into adulthood, but cannot be detected in any other tissues. The Cdx-1 gene is the first homeo-box-containing gene expressed in cells derived from the embryonic endoderm.

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