Reference : Direct effects of nicotine on rabbit preimplantation embryos.
Scientific journals : Article
Life sciences : Genetics & genetic processes
Direct effects of nicotine on rabbit preimplantation embryos.
Balling, Rudi mailto []
Beier, H. M. [> >]
Yes (verified by ORBilu)
[en] Animals ; Blastocyst/drug effects/metabolism ; DNA/biosynthesis ; Embryonic and Fetal Development/drug effects ; Female ; Nicotine/toxicity ; Pregnancy ; Rabbits
[en] The effects of various concentrations of nicotine on the in vitro development of 1-cell rabbit preimplantation embryos and on the DNA-synthesis of 4-day-old rabbit blastocysts are investigated. Exposure of rabbit preimplantation embryos to concentrations of nicotine higher than 1 X 10(-3) M results in a marked decrease in the in vitro development and in DNA-synthesis. Concentrations of nicotine below 1 X 10(-3) M have no effect on these early embryos. It can be concluded that the concentrations of nicotine which exert a direct embryotoxic effect are higher than the concentrations that may be expected in the blood circulation of humans considered to be "normal smokers".

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