Reference : Direct effects of nicotine on rabbit preimplantation embryos. |
Scientific journals : Article | |||
Life sciences : Genetics & genetic processes | |||
http://hdl.handle.net/10993/1251 | |||
Direct effects of nicotine on rabbit preimplantation embryos. | |
English | |
Balling, Rudi ![]() | |
Beier, H. M. [> >] | |
1985 | |
Toxicology | |
34 | |
4 | |
309-13 | |
Yes (verified by ORBilu) | |
0300-483X | |
NETHERLANDS | |
[en] Animals ; Blastocyst/drug effects/metabolism ; DNA/biosynthesis ; Embryonic and Fetal Development/drug effects ; Female ; Nicotine/toxicity ; Pregnancy ; Rabbits | |
[en] The effects of various concentrations of nicotine on the in vitro development of 1-cell rabbit preimplantation embryos and on the DNA-synthesis of 4-day-old rabbit blastocysts are investigated. Exposure of rabbit preimplantation embryos to concentrations of nicotine higher than 1 X 10(-3) M results in a marked decrease in the in vitro development and in DNA-synthesis. Concentrations of nicotine below 1 X 10(-3) M have no effect on these early embryos. It can be concluded that the concentrations of nicotine which exert a direct embryotoxic effect are higher than the concentrations that may be expected in the blood circulation of humans considered to be "normal smokers". | |
http://hdl.handle.net/10993/1251 |
There is no file associated with this reference.
All documents in ORBilu are protected by a user license.