Article (Scientific journals)
The nature of the starter unit for the rapamycin polyketide synthase
König, Ariane; Schwecke, T.; Molnár, I. et al.
1996In Angewandte Chemie International Edition, 35 (19), p. 2249-2251
 

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Keywords :
Macrolide; Streptomycetes
Abstract :
[en] A remarkably high level of incorporation is observed when 2,2,5,5-tetradeutero -3,4- dihydroxycyclo -hexanecarboxylic acid is fed to the rapamycin-producing organism. Intriguingly, however, analysis of the gene sequence for the rapamycin polyketide synthase has suggested that the free acid may not normally be involved in rapamycin biosynthesis.
Disciplines :
Life sciences: Multidisciplinary, general & others
Identifiers :
UNILU:UL-ARTICLE-2011-404
Author, co-author :
König, Ariane  ;  University of Cambridge
Schwecke, T.;  University of Cambridge
Molnár, I.;  University of Cambridge
Böhm, G. A.;  University of Cambridge > Department of Chemistry
Lowden, P. A. S.;  University of Cambridge > Department of Chemistry
Staunton, J.;  University of Cambridge > Department of Chemistry
Leadlay, P. F.;  University of Cambridge > Department of Biochemistry
External co-authors :
no
Language :
English
Title :
The nature of the starter unit for the rapamycin polyketide synthase
Publication date :
18 October 1996
Journal title :
Angewandte Chemie International Edition
ISSN :
1433-7851
Publisher :
VCH Verlagsgesellschaft mbH, Weinheim, Germany
Volume :
35
Issue :
19
Pages :
2249-2251
Available on ORBilu :
since 02 December 2013

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