Reference : The nature of the starter unit for the rapamycin polyketide synthase
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/12415
The nature of the starter unit for the rapamycin polyketide synthase
English
König, Ariane mailto [University of Cambridge]
Schwecke, T. [University of Cambridge]
Molnár, I. [University of Cambridge]
Böhm, G. A. [University of Cambridge > Department of Chemistry]
Lowden, P. A. S. [University of Cambridge > Department of Chemistry]
Staunton, J. [University of Cambridge > Department of Chemistry]
Leadlay, P. F. [University of Cambridge > Department of Biochemistry]
18-Oct-1996
Angewandte Chemie International Edition
VCH Verlagsgesellschaft mbH
35
19
2249-2251
No
International
1433-7851
Weinheim
Deutschland
[en] Macrolide ; Streptomycetes
[en] A remarkably high level of incorporation is observed when 2,2,5,5-tetradeutero -3,4- dihydroxycyclo -hexanecarboxylic acid is fed to the rapamycin-producing organism. Intriguingly, however, analysis of the gene sequence for the rapamycin polyketide synthase has suggested that the free acid may not normally be involved in rapamycin biosynthesis.
http://hdl.handle.net/10993/12415
10.1002/anie.199622491

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