Abstract :
[en] A remarkably high level of incorporation is observed when 2,2,5,5-tetradeutero -3,4- dihydroxycyclo -hexanecarboxylic acid is fed to the rapamycin-producing organism. Intriguingly, however, analysis of the gene sequence for the rapamycin polyketide synthase has suggested that the free acid may not normally be involved in rapamycin biosynthesis.
Schwecke, T.; University of Cambridge
Molnár, I.; University of Cambridge
Böhm, G. A.; University of Cambridge > Department of Chemistry
Lowden, P. A. S.; University of Cambridge > Department of Chemistry
Staunton, J.; University of Cambridge > Department of Chemistry
Leadlay, P. F.; University of Cambridge > Department of Biochemistry
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