The nature of the starter unit for the rapamycin polyketide synthase

Reference : The nature of the starter unit for the rapamycin polyketide synthase


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/10993/12415

Title :	The nature of the starter unit for the rapamycin polyketide synthase
Language :	English
Author, co-author :	König, Ariane [University of Cambridge]
	Schwecke, T. [University of Cambridge]
	Molnár, I. [University of Cambridge]
	Böhm, G. A. [University of Cambridge > Department of Chemistry]
	Lowden, P. A. S. [University of Cambridge > Department of Chemistry]
	Staunton, J. [University of Cambridge > Department of Chemistry]
	Leadlay, P. F. [University of Cambridge > Department of Biochemistry]
Publication date :	18-Oct-1996
Journal title :	Angewandte Chemie International Edition
Publisher :	VCH Verlagsgesellschaft mbH
Volume :	35
Issue/season :	19
Pages :	2249-2251
Peer reviewed :	No
Audience :	International
ISSN :	1433-7851
City :	Weinheim
Country :	Deutschland
Keywords :	[en] Macrolide ; Streptomycetes
Abstract :	[en] A remarkably high level of incorporation is observed when 2,2,5,5-tetradeutero -3,4- dihydroxycyclo -hexanecarboxylic acid is fed to the rapamycin-producing organism. Intriguingly, however, analysis of the gene sequence for the rapamycin polyketide synthase has suggested that the free acid may not normally be involved in rapamycin biosynthesis.
Permalink :	http://hdl.handle.net/10993/12415
DOI :	10.1002/anie.199622491

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