Article (Scientific journals)
Distinct antimicrobial peptide expression determines host species-specific bacterial associations
Franzenburg, Sören; Walter, Jonas; Künzel, Sven et al.
2013In Proceedings of the National Academy of Sciences of the United States of America, 110 (39), p. 3730–E3738
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Keywords :
host-microbe; Cnidaria; core microbiota
Abstract :
[en] Animals are colonized by coevolved bacterial communities, which contribute to the host’s health. This commensal microbiota is often highly specific to its host-species, inferring strong selective pressures on the associated microbes. Several factors, including diet, mucus composition, and the immune system have been proposed as putative determinants of host-associated bacterial communities. Here we report that species-specific antimicrobial peptides account for different bacterial communities associated with closely related species of the cnidarian Hydra. Gene family extensions for potent antimicrobial peptides, the arminins, were detected in four Hydra species, with each species possessing a unique composition and expression profile of arminins. For functional analysis, we inoculated arminin-deficient and control polyps with bacterial consortia characteristic for different Hydra species and compared their selective preferences by 454 pyrosequencing of the bacterial microbiota. In contrast to control polyps, arminin-deficient polyps displayed decreased potential to select for bacterial communities resembling their native microbiota. This finding indicates that species-specific antimicrobial peptides shape species-specific bacterial associations.
Research center :
Zoological Institute, Christian-Albrechts University of Kiel, 24098 Kiel, Germany;
Disciplines :
Immunology & infectious disease
Author, co-author :
Franzenburg, Sören
Walter, Jonas ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Künzel, Sven
Wang, Jun
Baines, John F
Bosch, Thomas C G
Fraune, Sebastian
Language :
English
Title :
Distinct antimicrobial peptide expression determines host species-specific bacterial associations
Publication date :
03 September 2013
Journal title :
Proceedings of the National Academy of Sciences of the United States of America
ISSN :
1091-6490
Publisher :
National Academy of Sciences, Washington, United States - District of Columbia
Volume :
110
Issue :
39
Pages :
E3730–E3738
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 11 October 2013

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