[en] Intelligence is associated with important life outcomes. Behavioral, genetic, structural, and functional brain correlates of intelligence have been studied for decades, but questions remain as to how genetics are related to trait expression and what intermediary role brain properties play. This study investigated these mediations in a representative sample of 434 individuals, comprising young and older adults. Polygenic scores (PGS) for intelligence were calculated. Resting-state EEG recordings were analyzed using graph theory quantifying functional connectivity across different frequencies. We tested whether global and local graph metrics like efficiency and clustering mediated the association between PGS and intelligence. PGS significantly predicted variance in intelligence and were related to frequency-specific graph metrics in areas predominantly located in parieto-frontal regions, which in turn were associated with intelligence. These findings, based on the first study linking PGS to intelligence using EEG-derived graph metrics, identify candidate pathways through which genetic variation may shape intelligence, providing a foundation for future hypothesis-driven investigations. Data for this study were collected as part of the Dortmund Vital Study ( https://www.researchprotocols.org/2022/3/e32352 ; ClinicalTrials.gov: NCT05155397).
Disciplines :
Neurosciences & behavior
Author, co-author :
Engler, Rebecca; Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany
Stammen, Christina; Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany
Arnau, Stefan; Department of Ergonomics, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany
Schneider Penate, Javier; Department of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, 44801, Bochum, Germany
Metzen, Dorothea; Institute of Psychology, Department of Educational Sciences and Psychology, TU Dortmund University, 44227, Dortmund, Germany
Digutsch, Jan; Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany ; Institute of Behavioral Science and Technology, University of St. Gallen, St. Gallen, 9000, Switzerland
Gajewski, Patrick D; Department of Ergonomics, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany
Getzmann, Stephan; Department of Ergonomics, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany
Fraenz, Christoph; Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany
Reinders, Jörg; Department of Toxicology, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany
Voelkle, Manuel C; Department of Psychology, Humboldt-Universität zu Berlin, 10117, Berlin, Germany
Streit, Fabian; Department Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany ; Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany ; Hector Institute for Artificial Intelligence in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany
Ocklenburg, Sebastian; Department of Psychology, Medical School Hamburg, 20457, Hamburg, Germany ; ICAN Institute for Cognitive and Affective Neuroscience, Medical School Hamburg, 20457, Hamburg, Germany ; Department of Biopsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, 44801, Bochum, Germany
Schneider, Daniel; Department of Ergonomics, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany
Burke, Michael; Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany
Hengstler, Jan G; Department of Toxicology, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany
Watzl, Carsten; Department of Immunology, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany
Nitsche, Michael A; Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany ; Bielefeld University, University Hospital OWL, Protestant Hospital of Bethel Foundation, University Clinic of Psychiatry and Psychotherapy, 33615, Bielefeld, Germany ; German Center for Mental Health (DZPG), partner site Bochum/Marburg, Bochum, Germany
KUMSTA, Robert ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Behavioural and Cognitive Sciences (DBCS) > Health and Behaviour ; German Center for Mental Health (DZPG), partner site Bochum/Marburg, Bochum, Germany ; Department of Genetic Psychology, Faculty of Psychology, Ruhr University Bochum, 44801, Bochum, Germany
Wascher, Edmund; Department of Ergonomics, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany ; German Center for Mental Health (DZPG), partner site Bochum/Marburg, Bochum, Germany
Genç, Erhan; Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany. genc@ifado.de
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