Cell stiffness; Cell-size; Channel geometry; Experimental and numerical studies; Flowing blood; Leucocytes; Red blood cell; Red cells; Vessel walls; White cell; Computational Mechanics; Modeling and Simulation; Fluid Flow and Transfer Processes
Abstract :
[en] Margination, a fundamental process in which leukocytes migrate from the flowing blood to the vessel wall, is well-documented in physiology. However, it is still an open question on how the differences in cell size and stiffness of white and red cells contribute to this phenomenon. To investigate the specific influence of cell stiffness, we conduct experimental and numerical studies on the segregation of a binary mixture of artificially stiffened red blood cells within a suspension of healthy cells. The resulting distribution of stiffened cells within the channel is found to depend on the channel geometry, as demonstrated with slit, rectangular, and cylindrical cross sections. Notably, an unexpected central peak in the distribution of stiffened red blood cells, accompanied by fourfold peaks at the corners, emerges in agreement with simulations. Our results unveil a nonmonotonic variation in segregation/margination concerning hematocrit and flow rate, challenging the prevailing belief that higher flow rates lead to enhanced margination.
Disciplines :
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others
Author, co-author :
Chachanidze, Revaz D.; Experimental Physics, Saarland University, Saarbrucken, Germany ; Aix Marseille Universite, CNRS, Centrale Marseille, IRPHE, Marseille, France
Aouane, Othmane ; Helmholtz Institute Erlangen-Nürnberg for Renewable Energy, Forschungszentrum Julich, Erlangen, Germany
Harting, Jens ; Helmholtz Institute Erlangen-Nürnberg for Renewable Energy, Forschungszentrum Julich, Erlangen, Germany ; Department of Chemical and Biological Engineering, Department of Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
WAGNER, Christian ; University of Luxembourg ; Experimental Physics, Saarland University, Saarbrucken, Germany
Leonetti, Marc; Aix Marseille Universite, CNRS, Centrale Marseille, IRPHE, Marseille, France ; Aix Marseille Universite, CNRS, Centrale Marseille, Marseille, France ; Aix Marseille Universite, CNRS, CINAM, Turing Centre for Living Systems, Marseille, France
External co-authors :
yes
Language :
English
Title :
Margination of artificially stiffened red blood cells
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