[en] 'Cellular psychology' is a new field of inquiry that studies dendritic mechanisms for adapting mental events to the current context, thus increasing their coherence, flexibility, effectiveness, and comprehensibility. Apical dendrites of neocortical pyramidal cells have a crucial role in cognition - those dendrites receive input from diverse sources, including feedback, and can amplify the cell's feedforward transmission if relevant in that context. Specialized subsets of inhibitory interneurons regulate this cooperative context-sensitive processing by increasing or decreasing amplification. Apical input has different effects on cellular output depending on whether we are awake, deeply asleep, or dreaming. Furthermore, wakeful thought and imagery may depend on apical input. High-resolution neuroimaging in humans supports and complements evidence on these cellular mechanisms from other mammals.
Disciplines :
Neurosciences & behavior
Author, co-author :
Phillips, William A ; Psychology, Faculty of Natural Sciences, University of Stirling, Stirling, FK9 4LA, UK. Electronic address: wap1@stir.ac.uk
Bachmann, Talis; Institute of Psychology, University of Tartu, Tartu, Estonia. Electronic address: talis.bachmann@ut.ee
SPRATLING, Michael ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Behavioural and Cognitive Sciences (DBCS) > Cognitive Science and Assessment
Muckli, Lars; Centre for Cognitive Neuroimaging, School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QB, UK, Imaging Centre of Excellence, College of Medical, Veterinary and Life Sciences, University of Glasgow and Queen Elizabeth University Hospital, Glasgow, UK
Petro, Lucy S; Centre for Cognitive Neuroimaging, School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QB, UK, Imaging Centre of Excellence, College of Medical, Veterinary and Life Sciences, University of Glasgow and Queen Elizabeth University Hospital, Glasgow, UK
Zolnik, Timothy; Department of Biochemistry, Charité Universitätsmedizin Berlin, Berlin 10117, Germany, Department of Biology, Humboldt Universität zu Berlin, Berlin 10117, Germany
External co-authors :
yes
Language :
English
Title :
Cellular psychology: relating cognition to context-sensitive pyramidal cells.
We acknowledge valuable discussions of cellular psychology with many colleagues in Stirling, Estonia, London, Glasgow, Berlin, and beyond. Many of those whose work we cite provided comments, all of which were useful, some crucial. Four anonymous reviewers made valuable contributions. L.M. and L.S.P. are funded by the European Union's Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 720270, 785907, and 945539 (Human Brain Project SGA1 SGA2, and SGA3), and from the Biotechnology and Biological Sciences Research Council (BBSRC, BBN010956/1) \u2018Layer-specific cortical feedback\u2019, awarded to L.M. and L.S.P. T.Z. is funded by Einstein Stiftung Berlin (EVF-2020-571). Fred Phillips helped generate Figure 1. No interests are declared.We acknowledge valuable discussions of cellular psychology with many colleagues in Stirling, Estonia, London, Glasgow, Berlin, and beyond. Many of those whose work we cite provided comments, all of which were useful, some crucial. Four anonymous reviewers made valuable contributions. L.M. and L.S.P. are funded by the European Union\u2019s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 720270, 785907, and 945539 (Human Brain Project SGA1 SGA2, and SGA3), and from the Biotechnology and Biological Sciences Research Council (BBSRC, BBN010956/1) \u2018Layer-specific cortical feedback\u2019, awarded to L.M. and L.S.P. T.Z. is funded by Einstein Stiftung Berlin (EVF-2020-571). Fred Phillips helped generate Figure 1 .
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