Article (Scientific journals)
Estimating sparse regression models in multi-task learning and transfer learning through adaptive penalisation
RAUSCHENBERGER, Armin; NAZAROV, Petr; GLAAB, Enrico
2025In Bioinformatics, p. 10.1093/bioinformatics/btaf406
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Keywords :
multi-task learning, transfer learning, sparse regression, feature selection, adaptive penalisation
Abstract :
[en] Here we propose a simple two-stage procedure for sharing information between related high-dimensional prediction or classification problems. In both stages, we perform sparse regression separately for each problem. While this is done without prior information in the first stage, we use the coefficients from the first stage as prior information for the second stage. Specifically, we designed feature-specific and sign-specific adaptive weights to share information on feature selection, effect directions and effect sizes between different problems. The proposed approach is applicable to multi-task learning as well as transfer learning. It provides sparse models (i.e., with few non-zero coefficients for each problem) that are easy to interpret. We show by simulation and application that it tends to select fewer features while achieving a similar predictive performance as compared to available methods. An implementation is available in the R package ‘sparselink’ (https://github.com/rauschenberger/sparselink).
Research center :
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group)
LIH - Luxembourg Institute of Health
Disciplines :
Computer science
Mathematics
Biochemistry, biophysics & molecular biology
Author, co-author :
RAUSCHENBERGER, Armin ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine > Biomedical Data Science > Team Enrico GLAAB ; Luxembourg Institute of Health > Department of Medical Informatics > Bioinformatics and Artificial Intelligence
NAZAROV, Petr  ;  Luxembourg Institute of Health > Department of Medical Informatics > Bioinformatics and Artificial Intelligence
GLAAB, Enrico   ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Biomedical Data Science
 These authors have contributed equally to this work.
External co-authors :
no
Language :
English
Title :
Estimating sparse regression models in multi-task learning and transfer learning through adaptive penalisation
Publication date :
2025
Journal title :
Bioinformatics
ISSN :
1367-4803
eISSN :
1367-4811
Publisher :
Oxford University Press, Oxford, United Kingdom
Pages :
10.1093/bioinformatics/btaf406
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
Development Goals :
3. Good health and well-being
FnR Project :
NCER/23/16695277
Name of the research project :
Clinnova - Federating Digital Medicine in Europe
Funders :
FNR - Fonds National de la Recherche
Funding number :
NCER/23/16695277
Available on ORBilu :
since 03 January 2025

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