Reference : LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal ...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity.
Petit, M. M. [> >]
Fradelizi, J. [> >]
Golsteyn, R. M. [> >]
Ayoubi, T. A. [> >]
Menichi, B. [> >]
Louvard, D. [> >]
Van de Ven, W. J. [> >]
Friederich, Evelyne mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Molecular biology of the cell
Yes (verified by ORBilu)
[en] 3T3 Cells ; Amino Acid Sequence ; Animals ; Artificial Gene Fusion ; Binding Sites ; Caco-2 Cells ; Cell Adhesion Molecules/metabolism ; Cell Line, Transformed ; Cell Nucleus/metabolism ; Cercopithecus aethiops ; Cytoskeletal Proteins/genetics/immunology/metabolism ; Fatty Acids, Unsaturated/pharmacology ; Gene Expression ; Glycoproteins ; HL-60 Cells ; HeLa Cells ; High Mobility Group Proteins/genetics ; Humans ; LIM Domain Proteins ; LLC-PK1 Cells ; Metalloproteins/chemistry ; Mice ; Microfilament Proteins ; Molecular Sequence Data ; Phosphoproteins/metabolism ; Protein Sorting Signals ; Rabbits ; Swine ; Transcriptional Activation ; Vero Cells ; Zyxin
[en] The LPP gene is the preferred translocation partner of the HMGIC gene in a subclass of human benign mesenchymal tumors known as lipomas. Here we have characterized the LPP gene product that shares 41% of sequence identity with the focal adhesion protein zyxin. LPP localizes in focal adhesions as well as in cell-to-cell contacts, and it binds VASP, a protein implicated in the control of actin organization. In addition, LPP accumulates in the nucleus of cells upon treatment with leptomycin B, an inhibitor of the export factor CRM1. The nuclear export of LPP depends on an N-terminally located leucine-rich sequence that shares sequence homology with well-defined nuclear export signals. Moreover, LPP displays transcriptional activation capacity, as measured by GAL4-based assays. Altogether, these results show that the LPP protein has multifunctional domains and may serve as a scaffold upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.

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