[en] Dynamic processes such as cell migration and division depend on the actin cytoskeleton, a dense meshwork of protein polymers capable of undergoing rapid cycles of assembly and disassembly, under the control of a large number of actin-associated proteins. In cancer cells, structural and functional perturbations of the actin cytoskeleton correlate with higher proliferation rates and uncontrolled movement. Therefore, small molecules that act on the actin cytoskeleton of tumour cells and thus inhibit cell division and movement, may be of high therapeutic value. The dynamic properties of the actin cytoskeleton and the mechanism of action of actin-targeting drugs will be described.
Disciplines :
Biochimie, biophysique & biologie moléculaire
Auteur, co-auteur :
Giganti, Adeline
FRIEDERICH, Evelyne ; University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Langue du document :
Anglais
Titre :
The actin cytoskeleton as a therapeutic target: state of the art and future directions.
Date de publication/diffusion :
2003
Titre du périodique :
Progress in Cell Cycle Research
ISSN :
1087-2957
Maison d'édition :
Kluwer Academic/Plenum Publishers, Etats-Unis - New York
