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The actin cytoskeleton as a therapeutic target: state of the art and future directions.
Giganti, Adeline; Friederich, Evelyne
2003In Progress in Cell Cycle Research, 5, p. 511-25
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Keywords :
Actin Cytoskeleton/drug effects/metabolism; Actins/drug effects/metabolism; Animals; Antineoplastic Agents/pharmacology; Cell Division/drug effects/physiology; Cell Movement/drug effects/physiology; Cytoskeleton/drug effects/metabolism; Drug Evaluation, Preclinical/trends; Forecasting; Humans; Neoplasms/drug therapy/metabolism/physiopathology
Abstract :
[en] Dynamic processes such as cell migration and division depend on the actin cytoskeleton, a dense meshwork of protein polymers capable of undergoing rapid cycles of assembly and disassembly, under the control of a large number of actin-associated proteins. In cancer cells, structural and functional perturbations of the actin cytoskeleton correlate with higher proliferation rates and uncontrolled movement. Therefore, small molecules that act on the actin cytoskeleton of tumour cells and thus inhibit cell division and movement, may be of high therapeutic value. The dynamic properties of the actin cytoskeleton and the mechanism of action of actin-targeting drugs will be described.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Giganti, Adeline
Friederich, Evelyne ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Language :
Title :
The actin cytoskeleton as a therapeutic target: state of the art and future directions.
Publication date :
Journal title :
Progress in Cell Cycle Research
Publisher :
Kluwer Academic/Plenum Publishers, United States - New York
Volume :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
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