Reference : The actin cytoskeleton as a therapeutic target: state of the art and future directions.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
The actin cytoskeleton as a therapeutic target: state of the art and future directions.
Giganti, Adeline [> >]
Friederich, Evelyne mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Progress in cell cycle research
Yes (verified by ORBilu)
United States
[en] Actin Cytoskeleton/drug effects/metabolism ; Actins/drug effects/metabolism ; Animals ; Antineoplastic Agents/pharmacology ; Cell Division/drug effects/physiology ; Cell Movement/drug effects/physiology ; Cytoskeleton/drug effects/metabolism ; Drug Evaluation, Preclinical/trends ; Forecasting ; Humans ; Neoplasms/drug therapy/metabolism/physiopathology
[en] Dynamic processes such as cell migration and division depend on the actin cytoskeleton, a dense meshwork of protein polymers capable of undergoing rapid cycles of assembly and disassembly, under the control of a large number of actin-associated proteins. In cancer cells, structural and functional perturbations of the actin cytoskeleton correlate with higher proliferation rates and uncontrolled movement. Therefore, small molecules that act on the actin cytoskeleton of tumour cells and thus inhibit cell division and movement, may be of high therapeutic value. The dynamic properties of the actin cytoskeleton and the mechanism of action of actin-targeting drugs will be described.

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