Reference : Regulation of apoptosis in the immune system
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Regulation of apoptosis in the immune system
Krammer, P. H. [> >]
Behrmann, Iris mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Daniel, P. T. [> >]
Dhein, J. [> >]
Debatin, K. M. [> >]
Current Opinion in Immunology
Current Biology
Yes (verified by ORBilu)
United Kingdom
[en] Animals ; Apoptosis ; B-Lymphocytes ; Humans ; Neoplasms ; T-Lymphocytes
[en] Apoptosis in T and B lymphocytes is involved in all fundamental processes in the immune system. It is a mechanism to regulate the course of an immune response and to establish immunological memory as well as central and peripheral tolerance. Apoptosis in lymphocytes is regulated by gene products that induce or block this process. Elucidating the molecular basis for sensitivity and resistance towards induction of apoptosis is the key to the understanding of the development of the immune system, basic immune reactions and the pathogenesis of autoimmune diseases, AIDS and cancer.

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