No full text
Article (Scientific journals)
Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA
Terstegen, L.; Maassen, B. G.; Radtke, S. et al.
2000In FEBS Letters, 478 (1-2), p. 100-4
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Transfection; Receptors, Interleukin; Receptors, Cytokine; Proteins; Protein-Tyrosine Kinases; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Peptides; Receptors, Interleukin-5; Receptors, OSM-LIF; Receptors, Oncostatin M; Transcription Factors; Trans-Activators; Tetradecanoylphorbol Acetate; Suppressor of Cytokine Signaling Proteins; STAT3 Transcription Factor; STAT1 Transcription Factor; Repressor Proteins; Recombinant Fusion Proteins; Oncostatin M; Mitogen-Activated Protein Kinases; Enzyme Activation; Dimerization; DNA-Binding Proteins; Cytokine Receptor gp130; Cell Line; Binding Sites; Antigens, CD; Animals; Growth Inhibitors; Humans; Interleukin-5; Membrane Glycoproteins; MAP Kinase Signaling System; Lymphokines; Leukemia Inhibitory Factor Receptor alpha Subunit; Leukemia Inhibitory Factor; Janus Kinase 1; Intracellular Signaling Peptides and Proteins; Interleukin-6; Amino Acid Motifs
Abstract :
[en] Prior activation of mitogen-activated protein kinases by phorbol 13-myristate 12-acetate (PMA) results in an inhibition of interleukin (IL)-6-induced activation of the Janus kinase/signal transducer and activator of transcription (STAT) signaling pathway which is most likely mediated by the induction of suppressor of cytokine signaling-3 and requires the specific SHP2 binding site Y759 of the IL-6 signal transducer gp130. In this study, we demonstrate that PMA inhibits STAT activation by IL-6 and the related cytokine leukemia inhibitory factor (LIF) but not by oncostatin M (OSM). Since the LIF receptor also contains an SHP2 recruitment site whereas the OSM receptor lacks such a module, we propose that two SHP2 binding modules within a homo- or heterodimeric receptor are necessary to mediate the PMA inhibitory effect.
Disciplines :
Biochemistry, biophysics & molecular biology
Identifiers :
UNILU:UL-ARTICLE-2008-733
Author, co-author :
Terstegen, L.
Maassen, B. G.
Radtke, S.
BEHRMANN, Iris ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Schaper, F.
Heinrich, P. C.
Graeve, L.
Gatsios, P.
Language :
English
Title :
Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA
Publication date :
2000
Journal title :
FEBS Letters
ISSN :
0014-5793
eISSN :
1873-3468
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
478
Issue :
1-2
Pages :
100-4
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 18 September 2013

Statistics


Number of views
69 (0 by Unilu)
Number of downloads
0 (0 by Unilu)

Scopus citations®
 
5
Scopus citations®
without self-citations
5
WoS citations
 
5

Bibliography


Similar publications



Contact ORBilu