| Reference : Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/10993/6258 | |||
| Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA | |
| English | |
| Terstegen, L. [> >] | |
| Maassen, B. G. [> >] | |
| Radtke, S. [> >] | |
Behrmann, Iris  [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >] | |
| Schaper, F. [> >] | |
| Heinrich, P. C. [> >] | |
| Graeve, L. [> >] | |
| Gatsios, P. [> >] | |
| 2000 | |
| FEBS Letters | |
| Elsevier Science | |
| 478 | |
| 1-2 | |
| 100-4 | |
| Yes (verified by ORBilu) | |
| International | |
| 0014-5793 | |
| Amsterdam | |
| The Netherlands | |
| [en] Transfection ; Receptors, Interleukin ; Receptors, Cytokine ; Proteins ; Protein-Tyrosine Kinases ; Protein Tyrosine Phosphatases ; Protein Tyrosine Phosphatase, Non-Receptor Type 6 ; Protein Tyrosine Phosphatase, Non-Receptor Type 11 ; Peptides ; Receptors, Interleukin-5 ; Receptors, OSM-LIF ; Receptors, Oncostatin M ; Transcription Factors ; Trans-Activators ; Tetradecanoylphorbol Acetate ; Suppressor of Cytokine Signaling Proteins ; STAT3 Transcription Factor ; STAT1 Transcription Factor ; Repressor Proteins ; Recombinant Fusion Proteins ; Oncostatin M ; Mitogen-Activated Protein Kinases ; Enzyme Activation ; Dimerization ; DNA-Binding Proteins ; Cytokine Receptor gp130 ; Cell Line ; Binding Sites ; Antigens, CD ; Animals ; Growth Inhibitors ; Humans ; Interleukin-5 ; Membrane Glycoproteins ; MAP Kinase Signaling System ; Lymphokines ; Leukemia Inhibitory Factor Receptor alpha Subunit ; Leukemia Inhibitory Factor ; Janus Kinase 1 ; Intracellular Signaling Peptides and Proteins ; Interleukin-6 ; Amino Acid Motifs | |
| [en] Prior activation of mitogen-activated protein kinases by phorbol 13-myristate 12-acetate (PMA) results in an inhibition of interleukin (IL)-6-induced activation of the Janus kinase/signal transducer and activator of transcription (STAT) signaling pathway which is most likely mediated by the induction of suppressor of cytokine signaling-3 and requires the specific SHP2 binding site Y759 of the IL-6 signal transducer gp130. In this study, we demonstrate that PMA inhibits STAT activation by IL-6 and the related cytokine leukemia inhibitory factor (LIF) but not by oncostatin M (OSM). Since the LIF receptor also contains an SHP2 recruitment site whereas the OSM receptor lacks such a module, we propose that two SHP2 binding modules within a homo- or heterodimeric receptor are necessary to mediate the PMA inhibitory effect. | |
| http://hdl.handle.net/10993/6258 |
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