| Reference : Termination of IL-6-induced STAT activation is independent of receptor internalizatio... |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/10993/6256 | |||
| Termination of IL-6-induced STAT activation is independent of receptor internalization but requires de novo protein synthesis | |
| English | |
| Thiel, S. [> >] | |
| Sommer, U. [> >] | |
| Kortylewski, M. [> >] | |
Haan, Claude  [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >] | |
| Behrmann, Iris [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >] | |
| Heinrich, P. C. [> >] | |
| Graeve, L. [> >] | |
| 2000 | |
| FEBS Letters | |
| Elsevier Science | |
| 470 | |
| 1 | |
| 15-9 | |
| Yes (verified by ORBilu) | |
| International | |
| 0014-5793 | |
| Amsterdam | |
| The Netherlands | |
| [en] Animals ; Phosphorylation ; Protein Tyrosine Phosphatase, Non-Receptor Type 11 ; Protein Tyrosine Phosphatase, Non-Receptor Type 6 ; Protein Tyrosine Phosphatases ; Receptors, Interleukin-6 ; STAT1 Transcription Factor ; STAT3 Transcription Factor ; Trans-Activators ; Mice ; Membrane Glycoproteins ; Intracellular Signaling Peptides and Proteins ; Antigens, CD ; Cell Line ; Cytokine Receptor gp130 ; DNA-Binding Proteins ; Endocytosis ; Erythropoietin ; Humans ; Interleukin-6 ; Tumor Cells, Cultured | |
| [en] The interleukin-6 (IL-6) receptor complex comprises the IL-6 receptor (IL-6R, gp80) and the signal transducer gp130. Binding of IL-6 to its receptor results in dimerization of gp130, activation of the Jak/STAT pathway, and in a down-regulation of IL-6 binding sites by endocytosis. The STAT activation after stimulation is transient, being maximal after 15-30 min and disappearing after 60-90 min. The mechanism which leads to the termination of the signal is still unknown.In this paper we have studied whether the down-modulation of the STAT signal requires the endocytosis of the receptor complex. Our results suggest that the desensitization of the IL-6 signal is not due to internalization of the receptor complex but requires de novo protein synthesis. | |
| http://hdl.handle.net/10993/6256 |
There is no file associated with this reference.
All documents in ORBilu are protected by a user license.
