| Reference : Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protei... |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/10993/6249 | |||
| Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor | |
| English | |
| Hermanns, H. M. [> >] | |
| Radtke, S. [> >] | |
| Schaper, F. [> >] | |
| Heinrich, P. C. [> >] | |
Behrmann, Iris  [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >] | |
| 2001 | |
| Journal of Biological Chemistry | |
| American Society for Biochemistry and Molecular Biology | |
| 275 | |
| 52 | |
| 40742-8 | |
| Yes (verified by ORBilu) | |
| International | |
| 0021-9258 | |
| 1083-351X | |
| Baltimore | |
| MD | |
| [en] Adaptor Proteins, Signal Transducing ; Peptides ; Promoter Regions (Genetics) ; Proteins ; Rats ; Receptors, Cytokine ; Receptors, Oncostatin M ; Signal Transduction ; Tyrosine ; Oncostatin M ; Mitogen-Activated Protein Kinases ; Lymphokines ; Adaptor Proteins, Vesicular Transport ; Animals ; COS Cells ; Dimerization ; GRB2 Adaptor Protein ; Growth Inhibitors ; Interleukin-6 ; Leukemia Inhibitory Factor ; alpha-Macroglobulins | |
| [en] The common use of the cytokine receptor gp130 has served as an explanation for the extremely redundant biological activities exerted by interleukin (IL)-6-type cytokines. Indeed, hardly any differences in signal transduction initiated by these cytokines are known. In the present study, we demonstrate that oncostatin M (OSM), but not IL-6 or leukemia inhibitory factor, induces tyrosine phosphorylation of the Shc isoforms p52 and p66 and their association with Grb2. Concomitantly, OSM turns out to be a stronger activator of ERK1/2 MAPKs. Shc is recruited to the OSM receptor (OSMR), but not to gp130. Binding involves Tyr(861) of the OSMR, located within a consensus binding sequence for the Shc PTB domain. Moreover, Tyr(861) is essential for activation of ERK1/2 and for full activation of the alpha(2)-macroglobulin promoter, but not for an exclusively STAT-responsive promoter. This study therefore provides evidence for qualitative differential signaling mechanisms exerted by IL-6-type cytokines. | |
| http://hdl.handle.net/10993/6249 | |
| 10.1074/jbc.M005408200 |
There is no file associated with this reference.
All documents in ORBilu are protected by a user license.
