ROS; RedOx balance; bioenergetics; biosynthesis; cancer metabolism; hypoxia; metabolic plasticity; metastasis; one-carbon metabolism; tumour microenvironment; Disease Progression; Humans; Neoplasm Metastasis/pathology; Neoplasms/metabolism; Neoplasm Metastasis; Neoplasms; Biochemistry, Genetics and Molecular Biology (all); General Medicine
Abstract :
[en] The metastatic cascade is a highly plastic and dynamic process dominated by cellular heterogeneity and varying metabolic requirements. During this cascade, the three major metabolic pillars, namely biosynthesis, RedOx balance, and bioenergetics, have variable importance. Biosynthesis has superior significance during the proliferation-dominated steps of primary tumour growth and secondary macrometastasis formation and only minor relevance during the growth-independent processes of invasion and dissemination. Consequently, RedOx homeostasis and bioenergetics emerge as conceivable metabolic key determinants in cancer cells that disseminate from the primary tumour. Within this review, we summarise our current understanding on how cancer cells adjust their metabolism in the context of different microenvironments along the metastatic cascade. With the example of one-carbon metabolism, we establish a conceptual view on how the same metabolic pathway can be exploited in different ways depending on the current cellular needs during metastatic progression.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
BENZARTI, Mohaned ✱; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) ; Cancer Metabolism Group, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg
Delbrouck, Catherine ✱; Cancer Metabolism Group, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg ; Faculty of Science, Technology and Medicine, University of Luxembourg, 2 Avenue de l'Université, L-4365 Esch-sur-Alzette, Luxembourg
Neises, Laura; Cancer Metabolism Group, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg
Kiweler, Nicole ✱; Cancer Metabolism Group, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg
Meiser, Johannes ✱; Cancer Metabolism Group, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg
✱ These authors have contributed equally to this work.
External co-authors :
no
Language :
English
Title :
Metabolic Potential of Cancer Cells in Context of the Metastatic Cascade.