Botulinum Neurotoxin Type A Subtype 2 Confers Greater Safety than Subtype 1 in a Rat Parkinson’s Disease Model

[en] Botulinum neurotoxin type A (BoNT/A) cleaves SNAP-25 and interrupts the release of acetylcholine. We previously reported that BoNT/A subtype 2 (BoNT/A2) ameliorates pathologic behavior more effectively than subtype 1 (BoNT/A1) in a rat Parkinson’s disease model. Here, we further show BoNT/A2 has fewer adverse effects than BoNT/A1. We first confirmed that intrastriatal treatments of both BoNT/As had no-effect on dopaminergic terminals in the striatum. SNAP-25 cleaved by BoNT/A2 was strictly localized to the striatum on the injected side; however, SNAP-25 cleaved by BoNT/A1 diffused contralaterally. Furthermore, treatment with BoNT/A1 caused a significant reduction in body weight, while BoNT/A2 treatment did not. These results suggest that BoNT/A2 is more beneficial for clinical application against Parkinson’s disease than BoNT/A1.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

ITAKURA, Masanori ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Neuroinflammation Group

KOHDA, Tomoko

KUBO, Takeya

SEMI, Yuko

NISHIYAMA, Kazuhiro

AZUMA, Yasu-Taka

NAKAJIMA, Hidemitsu

KOZAKI, Shunji

TAKEUCHI, Tadayoshi

External co-authors :

yes

Language :

English

Title :

Botulinum Neurotoxin Type A Subtype 2 Confers Greater Safety than Subtype 1 in a Rat Parkinson’s Disease Model

Publication date :

2014

Journal title :

Journal of Veterinary Medical Science

ISSN :

0916-7250

eISSN :

1347-7439

Publisher :

Maruzen Co., Ltd/Maruzen Kabushikikaisha, Jp

Volume :

Issue :

Pages :

1189-1193

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://app.readcube.com/library/a9ec3f18-47dd-4e50-bc89-1e8528daa3d7/item/c581ff39-fcf6-43a6-8bc2-39d96da77229

Available on ORBilu :

since 29 November 2023

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Bibliography

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