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Binding characteristics of [125I]endothelin-1 in guinea-pig trachea and its displacement by endothelin-1, endothelin-3 and endothelin (16-21)
Tschirhart, Eric; Pelton, J. T.; Jones, C. R.
1991In Agents and Actions. Supplements, 31, p. 233-6
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Keywords :
Animals; metabolism; Trachea; Tissue Distribution; Peptide Fragments; Iodine Radioisotopes; Guinea Pigs; Endothelins; Binding, Competitive; Binding Sites; diagnostic use
Abstract :
[en] The presence of binding sites for endothelin-1 (ET-1) and endothelin-3 (ET-3) in airway epithelium, submucosa and smooth muscle of guinea-pig trachea was investigated using in vitro autoradiography. We also examined the ability of the C-terminal hexapeptide of endothelin, ET(16-21) to inhibit specific [125I]ET-1, binding. ET-1 appeared to bind to a single class of binding sites (nH not different from unity). In contrast, nH values for ET-3 displacement of [125I]ET-1 specific binding were different from unity, suggesting that these peptides bound to more than one site. ET (16-21) did not affect [125I]ET-1 binding. The present results suggest that the binding sites identified in guinea pig airway smooth muscle may be related to receptors mediating contractile responses to the endothelins.
Disciplines :
Biochemistry, biophysics & molecular biology
Identifiers :
UNILU:UL-ARTICLE-2008-221
Author, co-author :
Tschirhart, Eric ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Pelton, J. T.
Jones, C. R.
Language :
English
Title :
Binding characteristics of [125I]endothelin-1 in guinea-pig trachea and its displacement by endothelin-1, endothelin-3 and endothelin (16-21)
Publication date :
1991
Journal title :
Agents and Actions. Supplements
ISSN :
0379-0363
Publisher :
Birkhäuser, Basel, Germany
Volume :
31
Pages :
233-6
Peer reviewed :
Peer reviewed
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