| Reference : Binding characteristics of [125I]endothelin-1 in guinea-pig trachea and its displacem... |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/10993/5753 | |||
| Binding characteristics of [125I]endothelin-1 in guinea-pig trachea and its displacement by endothelin-1, endothelin-3 and endothelin (16-21) | |
| English | |
Tschirhart, Eric  [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >] | |
| Pelton, J. T. [> >] | |
| Jones, C. R. [> >] | |
| 1991 | |
| Agents and Actions. Supplements | |
| Birkhäuser | |
| 31 | |
| 233-6 | |
| Yes | |
| 0379-0363 | |
| Basel | |
| Deutschland | |
| [en] Animals ; metabolism ; Trachea ; Tissue Distribution ; Peptide Fragments ; Iodine Radioisotopes ; Guinea Pigs ; Endothelins ; Binding, Competitive ; Binding Sites ; diagnostic use | |
| [en] The presence of binding sites for endothelin-1 (ET-1) and endothelin-3 (ET-3) in airway epithelium, submucosa and smooth muscle of guinea-pig trachea was investigated using in vitro autoradiography. We also examined the ability of the C-terminal hexapeptide of endothelin, ET(16-21) to inhibit specific [125I]ET-1, binding. ET-1 appeared to bind to a single class of binding sites (nH not different from unity). In contrast, nH values for ET-3 displacement of [125I]ET-1 specific binding were different from unity, suggesting that these peptides bound to more than one site. ET (16-21) did not affect [125I]ET-1 binding. The present results suggest that the binding sites identified in guinea pig airway smooth muscle may be related to receptors mediating contractile responses to the endothelins. | |
| http://hdl.handle.net/10993/5753 |
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