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Molecular basis for cellular effects of naturally occurring polyamines
Bueb, Jean-Luc; Mousli, M.; Landry, Y.
1991In Agents and Actions, 33 (1-2), p. 84-7
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Keywords :
cytology; Pertussis Toxin; Peritoneal Cavity; Mast Cells; Male; Histamine Release; GTP-Binding Proteins; GTP Phosphohydrolases; Cadaverine; Polyamines; Putrescine; Rats; physiology; drug effects; metabolism; pharmacology; Virulence Factors, Bordetella; Spermine; Spermidine; Rats, Inbred Strains; Animals
Abstract :
[en] The naturally occurring polyamines, putrescine, spermidine and spermine, and the analogue cadaverine, induce a dose-dependent histamine release from rat peritoneal mast cells. Spermine was the most active among these polycationic metabolites, followed by spermidine and putrescine. The histamine release was inhibited by a 2 h pretreatment of the cells with pertussis toxin (100 ng/ml), demonstrating the involvement of a pertussis toxin-sensitive GTP-binding regulatory protein during the exocytotic process. Experiments performed with purified Go/Gi proteins reconstituted into phospholipid vesicles showed a direct stimulation of GTPase activity by the polyamines. This direct stimulation of G proteins and the consequent activation of the coupled effectors may represent a new mechanism of action for natural polyamines controlling receptor-dependent processes.
Disciplines :
Biochemistry, biophysics & molecular biology
Identifiers :
UNILU:UL-ARTICLE-2008-202
Author, co-author :
Bueb, Jean-Luc ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Mousli, M.
Landry, Y.
Language :
English
Title :
Molecular basis for cellular effects of naturally occurring polyamines
Publication date :
1991
Journal title :
Agents and Actions
ISSN :
0065-4299
Publisher :
Birkhauser Verlag, Basel, Switzerland
Volume :
33
Issue :
1-2
Pages :
84-7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 09 September 2013

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