Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer's Disease.

Alzheimer Disease/metabolism; Animals; Endoplasmic Reticulum/metabolism; Endoplasmic Reticulum Stress/physiology; Humans; Mitochondria/metabolism; Mitochondrial Membranes/metabolism; APOE; APP-C-terminal fragments (APP-CTFs); Alzheimer’s disease (AD); Amyloid β peptide (Aβ); Endoplasmic Reticulum (ER); Mitochondria-Associated Membranes (MAMs); Unfolded Protein Response (UPR); calcium signaling; cholesterol; fatty acid; lipids; mitochondria; phospholipids; tau; unfolded protein response; β amyloid precursor protein (APP)

Résumé :

[en] Alzheimer's disease (AD) is a multifactorial neurodegenerative pathology characterized by a progressive decline of cognitive functions. Alteration of various signaling cascades affecting distinct subcellular compartment functions and their communication likely contribute to AD progression. Among others, the alteration of the physical association between the endoplasmic reticulum (ER) and mitochondria, also reffered as mitochondria-associated membranes (MAMs), impacts various cellular housekeeping functions such as phospholipids-, glucose-, cholesterol-, and fatty-acid-metabolism, as well as calcium signaling, which are all altered in AD. Our review describes the physical and functional proteome crosstalk between the ER and mitochondria and highlights the contribution of distinct molecular components of MAMs to mitochondrial and ER dysfunctions in AD progression. We also discuss potential strategies targeting MAMs to improve mitochondria and ER functions in AD.

Disciplines :

Biochimie, biophysique & biologie moléculaire

Auteur, co-auteur :

Eysert, Fanny

Kinoshita, Paula Fernanda

MARY, Arnaud ; Université Côte d'Azur, INSERM, CNRS, IPMC, France, Laboratory of excellence DistALZ, 660 route des Lucioles,6560, Sophia-Antipolis, Valbonne, France.

Vaillant-Beuchot, Loan

Checler, Frédéric

Chami, Mounia

Co-auteurs externes :

yes

Langue du document :

Anglais

Titre :

Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer's Disease.

Date de publication/diffusion :

2020

Titre du périodique :

International Journal of Molecular Sciences

ISSN :

1661-6596

eISSN :

1422-0067

Maison d'édition :

Multidisciplinary Digital Publishing Institute (MDPI), Suisse

Volume/Tome :

Fascicule/Saison :

Peer reviewed :

Peer reviewed vérifié par ORBi

Disponible sur ORBilu :

depuis le 12 septembre 2023

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Nombre de vues

127 (dont 5 Unilu)

Nombre de téléchargements

45 (dont 2 Unilu)

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