Article (Scientific journals)
Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer's Disease.
Eysert, Fanny; Kinoshita, Paula Fernanda; Mary, Arnaud et al.
2020In International Journal of Molecular Sciences, 21 (24)
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Keywords :
Alzheimer Disease/metabolism; Animals; Endoplasmic Reticulum/metabolism; Endoplasmic Reticulum Stress/physiology; Humans; Mitochondria/metabolism; Mitochondrial Membranes/metabolism; APOE; APP-C-terminal fragments (APP-CTFs); Alzheimer’s disease (AD); Amyloid β peptide (Aβ); Endoplasmic Reticulum (ER); Mitochondria-Associated Membranes (MAMs); Unfolded Protein Response (UPR); calcium signaling; cholesterol; fatty acid; lipids; mitochondria; phospholipids; tau; unfolded protein response; β amyloid precursor protein (APP)
Abstract :
[en] Alzheimer's disease (AD) is a multifactorial neurodegenerative pathology characterized by a progressive decline of cognitive functions. Alteration of various signaling cascades affecting distinct subcellular compartment functions and their communication likely contribute to AD progression. Among others, the alteration of the physical association between the endoplasmic reticulum (ER) and mitochondria, also reffered as mitochondria-associated membranes (MAMs), impacts various cellular housekeeping functions such as phospholipids-, glucose-, cholesterol-, and fatty-acid-metabolism, as well as calcium signaling, which are all altered in AD. Our review describes the physical and functional proteome crosstalk between the ER and mitochondria and highlights the contribution of distinct molecular components of MAMs to mitochondrial and ER dysfunctions in AD progression. We also discuss potential strategies targeting MAMs to improve mitochondria and ER functions in AD.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Eysert, Fanny
Kinoshita, Paula Fernanda
Mary, Arnaud  ;  Université Côte d'Azur, INSERM, CNRS, IPMC, France, Laboratory of excellence DistALZ, 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.
Vaillant-Beuchot, Loan
Checler, Frédéric
Chami, Mounia
External co-authors :
Language :
Title :
Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer's Disease.
Publication date :
Journal title :
International Journal of Molecular Sciences
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Volume :
Issue :
Peer reviewed :
Peer Reviewed verified by ORBi
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