Lower gastric sensitivity in quiescent inflammatory bowel disease than in irritable bowel syndrome

[en] OBJECTIVE: Visceral hypersensitivity is considered a key symptom in inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), both of which seriously affect health-related quality of life (HrQoL). Previous findings are mostly based on invasive procedures that may interfere with the assessment of visceral perception. The current study, therefore, investigates whether IBD and IBS are characterized by altered perception of “natural” gastric distensions (“interoception”). METHODS: Twenty IBD patients in remission (13 Crohn‟s disease, 7 ulcerative colitis), 12 IBS patients, and 20/12 matched healthy control (HC) individuals, respectively, underwent the water load test, in which they could drink ad libitum until the subjective thresholds of satiation (stage 1) and fullness (stage 2) were reached. Gastric motility was assessed using electrogastrography. RESULTS: IBD patients drank significantly more water until satiation than IBS patients, whereas no differences between patients and HC groups were observed. Electrogastrographic patterns were comparable between groups, suggesting no pathologies in gastric motility in IBD or IBS. The amount of water consumed until satiation negatively correlated with HrQoL related Gastric interoception in IBD and IBS to bowel symptoms in IBD patients, but was positively associated with emotional well-being in IBS patients. CONCLUSION: Our findings implicate relative gastric hypersensitivity in IBS, and relative hyposensitivity in IBD patients, which are both related to specific HrQoL aspects.

Disciplines :

Neurosciences & behavior

Author, co-author :

SCHULZ, André ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Behavioural and Cognitive Sciences (DBCS)

Welsch, Sina-Katharina

Etringer, Sarah

HANSEN, Greta ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Behavioural and Cognitive Sciences (DBCS)

Milbert, Léa

SCHNEIDER, Jochen ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Medical Translational Research

Taddei, Gennaro

GOMEZ BRAVO, Raquel ; University of Luxembourg

LYGIDAKIS, Charilaos ; University of Luxembourg

VAN DYCK, Zoé ; University of Luxembourg

More authors (3 more)

External co-authors :

Language :

English

Title :

Lower gastric sensitivity in quiescent inflammatory bowel disease than in irritable bowel syndrome

Publication date :

2023

Journal title :

Physiology and Behavior

ISSN :

0031-9384

eISSN :

1873-507X

Publisher :

Elsevier, New-York, United States - New York

Volume :

270

Issue :

Pages :

114293

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBilu :

since 19 July 2023

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