No association between war-related trauma or PTSD symptom severity and epigenome-wide DNA methylation in Burundian refugees.

Mattonet, Katharina; Scharpf, Florian; Block, Katrin; KUMSTA, Robert; Hecker, Tobias

doi:10.1080/20008066.2023.2228155

Article (Scientific journals)

No association between war-related trauma or PTSD symptom severity and epigenome-wide DNA methylation in Burundian refugees.

Mattonet, Katharina; Scharpf, Florian; Block, Katrin et al.

2023 • In European Journal of Psychotraumatology, 14 (2), p. 2228155

Peer Reviewed verified by ORBi

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https://hdl.handle.net/10993/55553

DOI
10.1080/20008066.2023.2228155

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37405801

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Keywords :

Burundian refugee families; DNA methylation; PTSD; EWAS; WGCNA; war trauma

Abstract :

[en] Background: War-related trauma is associated with varying posttraumatic stress disorder (PTSD) prevalence rates in refugees. In PTSD development, differential DNA methylation (DNAm) levels associated with trauma exposure might be involved in risk versus resilience processes. Studies investigating DNAm profiles related to trauma exposure and PTSD among refugees remain sparse.Objective: The present epigenome-wide association study investigated associations between war-related trauma, PTSD, and altered DNAm patterns in Burundian refugee families with 110 children and their 207 female and male caregivers.Method: War-related trauma load and PTSD symptom severity were assessed in structured clinical interviews with standardised instruments. Epigenome-wide DNAm levels were quantified from buccal epithelia using the Illumina EPIC beadchip.Results: Controlling for biological confounders, no significant epigenome-wide DNAm alterations associated with trauma exposure or PTSD were identified in children or caregivers (FDRs > .05). Co-methylated positions derived as modules from weighted gene correlation network analyses were not significantly associated with either war-related trauma experience in children or caregivers or with PTSD.Conclusions: These results do not provide evidence for altered DNAm patterns associated with exposure to war-related trauma or PTSD.

Disciplines :

Neurosciences & behavior

Author, co-author :

Mattonet, Katharina

Scharpf, Florian

Block, Katrin

KUMSTA, Robert ; University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Behavioural and Cognitive Sciences (DBCS)

Hecker, Tobias

External co-authors :

yes

Language :

English

Title :

No association between war-related trauma or PTSD symptom severity and epigenome-wide DNA methylation in Burundian refugees.

Publication date :

2023

Journal title :

European Journal of Psychotraumatology

eISSN :

2000-8066

Publisher :

Co-Action Publishing, Sweden

Volume :

Issue :

Pages :

2228155

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBilu :

since 06 July 2023

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